Wei Bing, Yang Shuhua, Zhang Bo, Feng Yong
Department of Orthopaedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Onco Targets Ther. 2016 Jul 1;9:4015-22. doi: 10.2147/OTT.S102733. eCollection 2016.
Published studies reported that loss of function of the p15(INK4B) gene is caused by hypermethylation; however, whether or not the inactivation is associated with the incidence and clinical significance of multiple myeloma (MM) remains unclear. In this study, we performed a meta-analysis to quantitatively determine the effects of p15 hypermethylation on the incidence of MM. The related research articles in English and Chinese languages were evaluated. The data were extracted and assessed independently. The pooled data were analyzed and odds ratios were calculated and summarized. Sixteen eligible studies were selected for final analysis. We demonstrated that p15 hypermethylation is significantly higher in MM than that in normal bone marrow, as well as monoclonal gammopathy of undetermined significance. However, aberrant p15 hypermethylation was not significantly higher in advanced MM than that in early-stage MM. The results of this study reveal that p15 hypermethylation is correlated with an increased risk in the progression of monoclonal gammopathy of undetermined significance to MM. p15 hypermethylation, which induces the loss of function of the p15 gene, plays a critical role in the early tumorigenesis of MM and serves as a reputable diagnostic marker and potential drug target.
已发表的研究报告称，p15(INK4B)基因功能丧失是由高甲基化引起的；然而，这种失活是否与多发性骨髓瘤（MM）的发病率及临床意义相关仍不清楚。在本研究中，我们进行了一项荟萃分析，以定量确定p15高甲基化对MM发病率的影响。对中英文相关研究文章进行了评估。数据被独立提取和评估。对汇总数据进行分析，并计算和总结比值比。选择16项符合条件的研究进行最终分析。我们证明，MM中p15高甲基化显著高于正常骨髓以及意义未明的单克隆丙种球蛋白病。然而，晚期MM中异常p15高甲基化并不显著高于早期MM。本研究结果表明，p15高甲基化与意义未明的单克隆丙种球蛋白病进展为MM的风险增加相关。p15高甲基化诱导p15基因功能丧失，在MM的早期肿瘤发生中起关键作用，可作为可靠的诊断标志物和潜在的药物靶点。
