Vaid Haris M, Camacho Ximena, Granton John T, Mamdani Muhammad M, Yao Zhan, Singh Samantha, Juurlink David N, Gomes Tara
School of Medicine, Queen's University, 15 Arch Street, Kingston, ON, Canada K7L 3N6.
The Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G1 06, Toronto, ON, Canada M4N 3M5.
Can Respir J. 2016;2016:6279250. doi: 10.1155/2016/6279250. Epub 2016 Apr 11.
Background. There are no Canadian prevalence studies on pulmonary arterial hypertension (PAH) to date. We described the characteristics of treated PAH patients and the healthcare utilization and costs associated with PAH in a population of public drug plan beneficiaries in Ontario, Canada. Methods. A retrospective cross-sectional analysis was conducted between April 2010 and March 2011 to identify treated PAH patients using population-based health administrative databases. We investigated demographic and clinical characteristics of treated PAH patients and conducted a cohort study to determine treatment patterns, healthcare utilization, and associated costs, over a one-year follow-up period (March 2012). Results. We identified 326 treated PAH cases in Ontario's publicly funded drug plan. Overall mean age was 59.4 years (±20.3 years) and over 77% of cases were women (n = 251). Combination therapy was used to treat 22.9% (n = 69) of cases, costing an average of $4,569 (SD $1,544) per month. Median monthly healthcare costs were $264 (IQR $96-$747) for those who survived and $2,021 (IQR $993-$6,399) for those who died over a one-year period, respectively (p < 0.01). Conclusions. PAH care in Ontario is complex and has high healthcare costs. This data may help guide towards improved patient management.
背景。迄今为止，加拿大尚无关于肺动脉高压（PAH）的患病率研究。我们描述了加拿大安大略省公共药物计划受益人群中接受治疗的PAH患者的特征以及与PAH相关的医疗保健利用情况和费用。方法。在2010年4月至2011年3月期间进行了一项回顾性横断面分析，以使用基于人群的健康管理数据库识别接受治疗的PAH患者。我们调查了接受治疗的PAH患者的人口统计学和临床特征，并进行了一项队列研究，以确定在一年随访期（2012年3月）内的治疗模式、医疗保健利用情况和相关费用。结果。我们在安大略省的公共资助药物计划中识别出326例接受治疗的PAH病例。总体平均年龄为59.4岁（±20.3岁），超过77%的病例为女性（n = 251）。联合治疗用于治疗22.9%（n = 69）的病例，每月平均费用为4,569加元（标准差1,544加元）。在一年期间存活的患者每月医疗费用中位数为264加元（四分位间距96 - 747加元），死亡患者为2,021加元（四分位间距993 - 6,399加元），差异有统计学意义（p < 0.01）。结论。安大略省的PAH护理复杂且医疗费用高昂。这些数据可能有助于指导改善患者管理。
