Probst Thomas, Neumeier Susanne, Altmeppen Jürgen, Angerer Michael, Loew Thomas, Pieh Christoph
Department of Psychology, University of Regensburg, 93053 Regensburg, Germany; Department of Psychology and Psychotherapy, Witten/Herdecke University, Witten, 58448 Herdecke, Germany.
Interdisciplinary Pain Clinic, Weiden Hospital, 92637 Weiden, Germany.
Pain Res Manag. 2016;2016:3204914. doi: 10.1155/2016/3204914. Epub 2016 May 29.
Research has shown that pain is associated with disability and that depressed mood mediates the relationship between pain and disability. The question of whether duration of pain moderates these effects was addressed in this cross-sectional study with 356 chronic pain patients. A simple mediation model replicated the notion that depressed mood explains a significant proportion of the relationship between pain and disability (in the study at hand: 12%). A moderated mediation model revealed that the indirect effect of pain on disability through depressed mood is moderated by pain duration: while depressed mood did not mediate the effect of pain on disability in chronic pain patients with shorter pain duration, depressed mood significantly mediated the effect pain exerts on disability in chronic pain patients with longer pain duration. Pain duration did not moderate the direct effect of pain on disability. Implications of these findings for the treatment of chronic pain might be that targeting depressed mood is especially relevant in chronic pain patients with longer pain duration to reduce the effect of pain on disability.
研究表明，疼痛与残疾相关，且抑郁情绪在疼痛与残疾之间的关系中起中介作用。在这项针对356名慢性疼痛患者的横断面研究中，探讨了疼痛持续时间是否会调节这些影响。一个简单的中介模型重现了这样一种观点，即抑郁情绪解释了疼痛与残疾之间相当大比例的关系（在本研究中为12%）。一个有调节的中介模型显示，疼痛通过抑郁情绪对残疾的间接影响受到疼痛持续时间的调节：在疼痛持续时间较短的慢性疼痛患者中，抑郁情绪并未介导疼痛对残疾的影响，而在疼痛持续时间较长的慢性疼痛患者中，抑郁情绪显著介导了疼痛对残疾的影响。疼痛持续时间并未调节疼痛对残疾的直接影响。这些发现对慢性疼痛治疗的启示可能是，针对抑郁情绪在疼痛持续时间较长的慢性疼痛患者中尤为重要，以减少疼痛对残疾的影响。
