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本文引用的文献

1
Global Transcriptome Analysis of Primary Cerebrocortical Cells: Identification of Genes Regulated by Triiodothyronine in Specific Cell Types.原代大脑皮质细胞的全转录组分析：特定细胞类型中受三碘甲状腺原氨酸调控的基因鉴定
Cereb Cortex. 2017 Jan 1;27(1):706-717. doi: 10.1093/cercor/bhv273.
2
Xenopus tropicalis Genome Re-Scaffolding and Re-Annotation Reach the Resolution Required for In Vivo ChIA-PET Analysis.热带爪蟾基因组的重新支架搭建和重新注释达到了体内染色质相互作用分析所需的分辨率。
PLoS One. 2015 Sep 8;10(9):e0137526. doi: 10.1371/journal.pone.0137526. eCollection 2015.
3
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.视黄酸X受体（RXR）核受体异二聚体信号转导的结构机制。
Nat Commun. 2015 Aug 20;6:8013. doi: 10.1038/ncomms9013.
4
Pituitary specific retinoid-X receptor ligand interactions with thyroid hormone receptor signaling revealed by high throughput reporter and endogenous gene responses.通过高通量报告基因和内源性基因反应揭示垂体特异性视黄酸X受体配体与甲状腺激素受体信号传导的相互作用。
Toxicol In Vitro. 2015 Oct;29(7):1609-18. doi: 10.1016/j.tiv.2015.06.018. Epub 2015 Jun 19.
5
A unified architecture of transcriptional regulatory elements.转录调控元件的统一架构。
Trends Genet. 2015 Aug;31(8):426-33. doi: 10.1016/j.tig.2015.05.007. Epub 2015 Jun 11.
6
Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.甲状腺激素受体通过配体依赖性受体募集和染色质重塑实现转录激活。
Nat Commun. 2015 Apr 28;6:7048. doi: 10.1038/ncomms8048.
7
Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module.解读一个古老的、超保守的核受体增强子模块的调控逻辑。
Mol Endocrinol. 2015 Jun;29(6):856-72. doi: 10.1210/me.2014-1349. Epub 2015 Apr 13.
8
Enhancer activation requires trans-recruitment of a mega transcription factor complex.增强子激活需要一个大型转录因子复合物的反式招募。
Cell. 2014 Oct 9;159(2):358-73. doi: 10.1016/j.cell.2014.08.027.
9
Genome-wide discovery of drug-dependent human liver regulatory elements.全基因组范围内对药物依赖型人类肝脏调控元件的发现。
PLoS Genet. 2014 Oct 2;10(10):e1004648. doi: 10.1371/journal.pgen.1004648. eCollection 2014 Oct.
10
A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo.一种由核甲状腺激素受体TRβ对PI3激酶进行调节的快速细胞质机制，以及其在小鼠海马体突触体内成熟过程中作用的遗传学证据。
Endocrinology. 2014 Sep;155(9):3713-24. doi: 10.1210/en.2013-2058. Epub 2014 Jun 16.

甲状腺激素信号研究中的未来挑战

Futures Challenges in Thyroid Hormone Signaling Research.

作者信息

Flamant Frédéric

机构信息

École Normale Supérieure de Lyon, CNRS, INRA, Institut de Génomique Fonctionnelle de Lyon, Université Claude Bernard Lyon 1, Université de Lyon , Lyon , France.

出版信息

Front Endocrinol (Lausanne). 2016 Jun 22;7:58. doi: 10.3389/fendo.2016.00058. eCollection 2016.

DOI:10.3389/fendo.2016.00058
PMID:27445973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4916735/
Abstract

The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research.

摘要

甲状腺激素信号传导的经典途径涉及它与核受体（TRs）结合，这些核受体直接作用于许多基因的转录。最近的全基因组研究表明，TR对染色质的占据不足以激活基因表达的转录。相反，在某些情况下，细胞反应可能不需要TR与DNA结合。这为未来的研究留下了许多新问题有待解决。