甲状腺激素信号研究中的未来挑战
Futures Challenges in Thyroid Hormone Signaling Research.
作者信息
Flamant Frédéric
机构信息
École Normale Supérieure de Lyon, CNRS, INRA, Institut de Génomique Fonctionnelle de Lyon, Université Claude Bernard Lyon 1, Université de Lyon , Lyon , France.
出版信息
Front Endocrinol (Lausanne). 2016 Jun 22;7:58. doi: 10.3389/fendo.2016.00058. eCollection 2016.
Abstract
The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research.
摘要
甲状腺激素信号传导的经典途径涉及它与核受体（TRs）结合，这些核受体直接作用于许多基因的转录。最近的全基因组研究表明，TR对染色质的占据不足以激活基因表达的转录。相反，在某些情况下，细胞反应可能不需要TR与DNA结合。这为未来的研究留下了许多新问题有待解决。
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