Janssen Stefan, Käsmann Lukas, Cegla Robert, Rades Dirk
Private Practice of Radiation Oncology, D-30161 Hannover, Germany; Department of Radiation Oncology, University of Lübeck, D-23538 Lübeck, Germany.
Department of Radiation Oncology, University of Lübeck, D-23538 Lübeck, Germany.
Mol Clin Oncol. 2016 Aug;5(2):342-344. doi: 10.3892/mco.2016.933. Epub 2016 Jun 14.
The aim of the present study was to evaluate the outcome and toxicity of 3D conformal radiotherapy (RT) for persistent lymphoceles following surgery for urological cancer. A total of 6 patients with bladder (n=1) and prostate cancer (n=5), with persistent lymphoceles following surgery for a primary tumor were treated with total doses of 10-12 Gy (1 Gy single dose) after computed tomography (CT) based 3D planning in order to suspend secretion. No acute or chronic toxicities were observed. In 5 patients, secretion of lymph fluid resolved after RT and in 1 patient RT had no effect. After a mean follow-up of 21 months (range, 5-47 months), no patient suffered from any symptoms concerning his former lymphoceles. This is the first analysis, to the best of our knowledge, to evaluate a homogenous patient collective of urological cancer patients with persistent lymphoceles after surgery for the initial tumor. RT to lymphoceles in urological cancer patient is effective, very well-tolerated and should be offered to patients with persistent secretion following drainage.
本研究的目的是评估三维适形放疗（RT）对泌尿外科癌症手术后持续性淋巴囊肿的治疗效果和毒性。共有6例膀胱癌（n = 1）和前列腺癌（n = 5）患者，在接受原发性肿瘤手术后出现持续性淋巴囊肿，在基于计算机断层扫描（CT）的三维计划后，接受了10 - 12 Gy（单次剂量1 Gy）的总剂量放疗，以抑制淋巴液分泌。未观察到急性或慢性毒性反应。5例患者放疗后淋巴液分泌消失，1例患者放疗无效。平均随访21个月（范围5 - 47个月）后，没有患者出现与既往淋巴囊肿相关的任何症状。据我们所知，这是首次对泌尿外科癌症患者在接受初始肿瘤手术后出现持续性淋巴囊肿的同质患者群体进行评估。对泌尿外科癌症患者的淋巴囊肿进行放疗是有效的，耐受性良好，对于引流后仍有持续性分泌的患者应考虑采用。
