使用高频光声技术在脉动流条件下同时评估红细胞聚集和氧饱和度。
Simultaneous assessment of red blood cell aggregation and oxygen saturation under pulsatile flow using high-frequency photoacoustics.
作者信息
Bok Tae-Hoon, Hysi Eno, Kolios Michael C
机构信息
Department of Physics, Ryerson University, 350 Victoria Street, Toronto, Ontario, M5B 2K3 Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 209 Victoria Street, Toronto, Ontario, M5B 1T8, Canada.
出版信息
Biomed Opt Express. 2016 Jun 23;7(7):2769-80. doi: 10.1364/BOE.7.002769. eCollection 2016 Jul 1.
We investigate the feasibility of photoacoustic (PA) imaging for assessing the correlation between red blood cell (RBC) aggregation and the oxygen saturation (sO2) in a simulated pulsatile blood flow system. For the 750 and 850 nm illuminations, the PA amplitude (PAA) increased and decreased as the mean blood flow velocity decreased and increased, respectively, at all beat rates (60, 120 and 180 bpm). The sO2 also cyclically varied, in phase with the PAA for all beat rates. However, the linear correlation between the sO2 and the PAA at 850 nm was stronger than that at 750 nm. These results suggest that the sO2 can be correlated with RBC aggregation induced by decreased mean shear rate in pulsatile flow, and that the correlation is dependent on the optical wavelength. The hemodynamic properties of blood flow assessed by PA imaging may be used to provide a new biomarker for simultaneous monitoring blood viscosity related to RBC aggregation, oxygen delivery related to the sO2 and their clinical correlation.
我们研究了在模拟脉动血流系统中，光声（PA）成像用于评估红细胞（RBC）聚集与氧饱和度（sO2）之间相关性的可行性。对于750和850 nm的光照，在所有搏动率（60、120和180 bpm）下，随着平均血流速度降低和增加，PA振幅（PAA）分别增加和降低。sO2也呈周期性变化，在所有搏动率下均与PAA同相。然而，850 nm处sO2与PAA之间的线性相关性强于750 nm处。这些结果表明，sO2可能与脉动流中平均剪切率降低引起的RBC聚集相关，且这种相关性取决于光学波长。通过PA成像评估的血流动力学特性可用于提供一种新的生物标志物，以同时监测与RBC聚集相关的血液粘度、与sO2相关的氧输送及其临床相关性。
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