Nonaka S, Ohgami T, Yamashita K, Irifune H, Watanabe M, Tsukazaki N, Tanaka K, Yoshida H
Fukuoka Igaku Zasshi. 1989 May;80(5):221-6.
The synergistic effect of chlorinated chemicals and 0.1% griseofulvin on porphyrin metabolism was investigated. Feeds containing 0.1% 4-chloro-m-cresol, 0.1% cumarone or 0.25% trichloroacetic acid with or without 0.1% griseofulvin were given to dd-y strain mice respectively. The treatments were continued for 10 to 450 days, after which coproporphyrin and protoporphyrin in the erythrocytes and liver were analyzed. In the 0.1% griseofulvin alone group, protoporphyria was induced in 6 of 55 dd-y strain mice, although the other 49 mice did not show any abnormal porphyrin metabolism and the severity of the protoporphyria was mild in the 6 mice. In the 4-chloro-m-cresol group, a slight elevation of erythrocytic porphyrins was seen, but the difference was not statistically significant. Elevation of the hepatic porphyrins was not seen. Trichloroacetic acid and cumarone did not influence porphyrin metabolism, and also there was no synergistic effect of griseofulvin on porphyrinopathy. These results suggest that the three chemicals selected in this study are not capable of inducing porphyrinopathy.
研究了氯化化学品与0.1%灰黄霉素对卟啉代谢的协同作用。分别给dd-y品系小鼠喂食含0.1% 4-氯间甲酚、0.1%香豆酮或0.25%三氯乙酸且添加或不添加0.1%灰黄霉素的饲料。处理持续10至450天，之后分析红细胞和肝脏中的粪卟啉和原卟啉。在仅含0.1%灰黄霉素的组中，55只dd-y品系小鼠中有6只诱发了原卟啉症，尽管其他49只小鼠未表现出任何异常的卟啉代谢，且这6只小鼠中原卟啉症的严重程度较轻。在4-氯间甲酚组中，红细胞卟啉略有升高，但差异无统计学意义。未观察到肝脏卟啉升高。三氯乙酸和香豆酮不影响卟啉代谢，灰黄霉素对卟啉病也没有协同作用。这些结果表明，本研究中选择的三种化学品不能诱发卟啉病。
