Duraker Nüvit, Çaynak Zeynep Civelek, Trabulus Didem Can
Department of Surgery, SB Okmeydanı Training and Research Hospital, İstanbul, Turkey.
Department of Surgery, Bayındır Levent Hospital, İstanbul, Turkey.
J Gastrointest Cancer. 2017 Mar;48(1):8-12. doi: 10.1007/s12029-016-9859-8.
The presence of prostate-specific antigen (PSA) in colon cancer tissues has been shown, but its clinical significance has not been known yet in colorectal cancer patients. We investigated the prognostic significance of percent free PSA value (free PSA/total PSA × 100) in female patients with colorectal cancer.
The serum concentrations of total and free PSA were measured by solid-phase two-site immunoradiometric assay in 184 patients.
The cancer-specific survival (CSS) of patients with percent free PSA value ≥35 was significantly better compared to that of patients with percent free PSA value <35 (CSS rate was 82.9 and 55.5 %, respectively; log-rank x = 8135, p = 0.004). In multivariate Cox analysis, this percent free PSA threshold value had independent prognostic significance (relative risk 0.27, 95 % confidence interval 0.11-0.64, p = 0.003).
Percent free PSA value, calculated by serum total and free PSA levels, has prognostic significance in women with colorectal cancer. The studies with larger patient series, utilizing ultrasensitive PSA assays whose lowest detection limit is lower, are required for a clearer understanding of this issue.
已证实在结肠癌组织中存在前列腺特异性抗原（PSA），但其在结直肠癌患者中的临床意义尚不清楚。我们研究了游离PSA值百分比（游离PSA/总PSA×100）在女性结直肠癌患者中的预后意义。
采用固相双位点免疫放射分析法测定了184例患者血清中总PSA和游离PSA的浓度。
游离PSA值百分比≥35%的患者的癌症特异性生存率（CSS）显著优于游离PSA值百分比<35%的患者（CSS率分别为82.9%和55.5%；对数秩检验χ² = 8.135，p = 0.004）。在多因素Cox分析中，该游离PSA百分比阈值具有独立的预后意义（相对风险0.27，95%置信区间0.11 - 0.64，p = 0.003）。
通过血清总PSA和游离PSA水平计算得出的游离PSA值百分比在女性结直肠癌患者中具有预后意义。为更清楚地了解这一问题，需要开展更大样本量患者的研究，并采用最低检测限更低的超灵敏PSA检测方法。
