Santini D, Gelli M C, Mazzoleni G, Ricci M, Severi B, Pasquinelli G, Pelusi G, Martinelli G
Istituto di Anatomia Patologica, University of Bologna, Italy.
Hum Pathol. 1989 Aug;20(8):787-95. doi: 10.1016/0046-8177(89)90074-9.
The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuron-specific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.
对勃勒纳瘤（BT）的组织学、组织化学、免疫组织化学和超微结构特征进行了研究。将BT与移行膀胱细胞进行比较，发现这两种组织之间有密切的相似性。所有细胞层中丰富的糖原、嗜阿尔辛蓝/唾液酸黏液表面被膜以及嗜银细胞是BT和膀胱上皮的特征。免疫组织化学方面，在所检查的所有病例中均观察到嗜铬粒蛋白和神经元特异性烯醇化酶反应性。另一个相关发现是BT和尿路上皮中均存在储存5-羟色胺的细胞。此外，在BT和尿路上皮中发现癌胚抗原、上皮膜抗原和角蛋白反应，表明存在额外的抗原相似性。另外，超微结构发现恶性勃勒纳瘤与膀胱组织有许多共同特征。强调了BT独特的组织化学、超微结构和抗原模式，主要是移行型。
