State Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology, School of Life Sciences, Shandong University, Shanda Nanlu 27, Jinan, 250100, P. R. China.
Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
Chem Biodivers. 2016 Dec;13(12):1685-1690. doi: 10.1002/cbdv.201600123. Epub 2016 Nov 21.
In our continuing program to find new bioactive compounds from the Chinese liverworts, four new kaurane-type diterpenoids, (6β)-kaur-16-ene-6,9-diol (1), (6β,12β)-kaur-16-ene-6,9,12-triol (2), (6β)-kaur-16-ene-5,6,9-triol (3), and kaur-16-ene-9,19-diol (4), have been isolated from the Chinese liverwort Jungermannia comata Nees. Five known kaurane-type diterpenoids (5 - 9) and four known trachylobane-type diterpenoids (10 - 13) were also obtained. The structures of the new compounds were established unequivocally on the basis of spectroscopic data. The absolute configuration of compound 1 was established by comparing experimental and calculated electronic circular dichroism spectra.
在我们继续从中国地钱中寻找新的生物活性化合物的计划中，从中国地钱中分离得到了四个新的贝壳杉烷型二萜类化合物，(6β)-贝壳杉-16-烯-6,9-二醇(1)、(6β,12β)-贝壳杉-16-烯-6,9,12-三醇(2)、(6β)-贝壳杉-16-烯-5,6,9-三醇(3)和贝壳杉-16-烯-9,19-二醇(4)。还获得了五个已知的贝壳杉烷型二萜类化合物(5-9)和四个已知的拉帕烷型二萜类化合物(10-13)。新化合物的结构是根据光谱数据确定的。通过比较实验和计算的电子圆二色谱，确定了化合物 1 的绝对构型。
