从新西兰叶苔属植物中分离得到的具有细胞毒性的新对映-贝壳杉烯型二萜类化合物。

New ent-kaurene-type diterpenoids possessing cytotoxicity from the New Zealand liverwort Jungermannia species.

作者信息

Nagashima Fumihiro, Kasai Wakana, Kondoh Masuo, Fujii Makiko, Watanabe Yoshiteru, Braggins John Edward, Asakawa Yoshinori

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2003 Oct;51(10):1189-92. doi: 10.1248/cpb.51.1189.

DOI:10.1248/cpb.51.1189

PMID:14519928

Abstract

Two new ent-kaurene-type and a new rearranged ent-kaurene-type diterpenoids possessing cytotoxicity against a human leukemia cell line have been isolated from the New Zealand liverwort Jungermannia species, together with previously known ent-kaurene-type diterpenoids. Their structures were established based on extensive NMR techniques.

摘要

从新西兰叶苔类植物叶苔属物种中分离出两种新的对映-贝壳杉烯型和一种新的重排对映-贝壳杉烯型具有抗人白血病细胞系细胞毒性的二萜类化合物，以及先前已知的对映-贝壳杉烯型二萜类化合物。它们的结构是基于广泛的核磁共振技术确定的。