Emmorey Karen, McCullough Stephen, Weisberg Jill
San Diego State University, Laboratory for Language and Cognitive Neuroscience, 6495 Alvarado Road, Suite 200, San Diego, CA 92012, USA.
San Diego State University, Laboratory for Language and Cognitive Neuroscience, 6495 Alvarado Road, Suite 200, San Diego, CA 92012, USA.
Brain Lang. 2016 Sep;160:11-20. doi: 10.1016/j.bandl.2016.06.007. Epub 2016 Jul 21.
We investigated word-level reading circuits in skilled deaf readers (N=14; mean reading age=19.5years) and less skilled deaf readers (N=14; mean reading age=12years) who were all highly proficient users of American Sign Language. During fMRI scanning, participants performed a semantic decision (concrete concept?), a phonological decision (two syllables?), and a false-font control task (string underlined?). No significant group differences were observed with the full participant set. However, an analysis with the 10 most and 10 least skilled readers revealed that for the semantic task (vs. control task), proficient deaf readers exhibited greater activation in left inferior frontal and middle temporal gyri than less proficient readers. No group differences were observed for the phonological task. Whole-brain correlation analyses (all participants) revealed that for the semantic task, reading ability correlated positively with neural activity in the right inferior frontal gyrus and in a region associated with the orthography-semantics interface, located anterior to the visual word form area. Reading ability did not correlate with neural activity during the phonological task. Accuracy on the semantic task correlated positively with neural activity in left anterior temporal lobe (a region linked to conceptual processing), while accuracy on the phonological task correlated positively with neural activity in left posterior inferior frontal gyrus (a region linked to syllabification processes during speech production). Finally, reading comprehension scores correlated positively with vocabulary and print exposure measures, but not with phonological awareness scores.
我们调查了熟练的聋人读者（N = 14；平均阅读年龄 = 19.5岁）和不太熟练的聋人读者（N = 14；平均阅读年龄 = 12岁）的单词层面阅读回路，他们都是美国手语的高度熟练使用者。在功能磁共振成像扫描期间，参与者执行语义判断（具体概念？）、语音判断（两个音节？）和伪字体控制任务（下划线字符串？）。在整个参与者组中未观察到显著的组间差异。然而，对10名最熟练和10名最不熟练读者的分析表明，对于语义任务（与控制任务相比），熟练的聋人读者在左下额叶和颞中回的激活程度高于不太熟练的读者。在语音任务中未观察到组间差异。全脑相关性分析（所有参与者）表明，对于语义任务，阅读能力与右下额叶回以及位于视觉词形区前方与正字法 - 语义界面相关的区域的神经活动呈正相关。阅读能力与语音任务期间的神经活动无关。语义任务的准确性与左前颞叶（与概念处理相关的区域）的神经活动呈正相关，而语音任务的准确性与左后下额叶回（与言语产生过程中的音节划分过程相关的区域）的神经活动呈正相关。最后，阅读理解分数与词汇量和印刷品接触量指标呈正相关，但与语音意识分数无关。
