Fan Hong, Song Fujian, Gu Hai, Wang Jianming, Jia Guizhen, Lu Moyuan, Qian Jiao, Wang Lei, Shen Jiemiao, Ren Zhewen
Center for Health Policy and Management Research, Nanjing University, Nanjing, P.R.China.
Department of Social Medicine and Health Education, School of Public Health, Nanjing Medical University, Nanjing, P.R.China.
Oncotarget. 2016 Aug 16;7(33):53762-53771. doi: 10.18632/oncotarget.10742.
To reduce smoking-related diseases, a research priority is to develop effective interventions for smoking cessation, and evidence from randomized controlled trials (RCTs) is usually considered to be the most valid. However, findings from RCTs may still be misleading due to methodological flaws. This study aims to assess the quality of 1083 RCTs of smoking cessation interventions in 41 relevant Cochrane Systematic Reviews (CSRs). Logistic regression analysis was performed to identify significant variables associated with the quality of RCTs. It was found that evidence for smoking cessation from RCTs was predominantly from high income countries, and the overall quality was high in only 8.6% of the RCTs. High quality RCTs tended to have a larger sample size, to be more recently published, and conducted in multiple countries belonging to different income categories. In conclusion, the overall quality of RCTs of smoking cessation interventions is far from perfect, and more RCTs in less developed countries are required to generate high grade evidence for global tobacco control. Collaboration between researchers in developed and less developed countries should be encouraged.
为减少与吸烟相关的疾病，一个研究重点是开发有效的戒烟干预措施，而随机对照试验（RCT）的证据通常被认为是最有效的。然而，由于方法上的缺陷，RCT的结果可能仍然具有误导性。本研究旨在评估41项相关Cochrane系统评价（CSR）中1083项戒烟干预RCT的质量。进行逻辑回归分析以确定与RCT质量相关的显著变量。研究发现，RCT的戒烟证据主要来自高收入国家，只有8.6%的RCT总体质量较高。高质量的RCT往往样本量更大、发表时间更近，且在属于不同收入类别的多个国家进行。总之，戒烟干预RCT的总体质量远非完美，需要在欠发达国家开展更多RCT，以生成用于全球烟草控制的高级别证据。应鼓励发达国家和欠发达国家的研究人员开展合作。
