Sivakumar Dakshinamurthy, Sivaraman Thirunavukkarasu
Structural Biology Lab, Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA University, Thanjavur - 613401, Tamil Nadu, India.
Protein Pept Lett. 2016;23(10):932-941. doi: 10.2174/0929866523666160719094636.
Cancer cells evade apoptosis, which is regulated by proteins of Bcl-2 family in the intrinsic pathways. Numerous experimental three-dimensional (3D) structures of the apoptotic proteins and the proteins bound with small chemical molecules/peptides/proteins have been reported in the literature. In this review article, the 3D structures of the Bcl-2 family proteins from Homo sapiens and as well complex structures of the anti-apoptotic proteins bound with small molecular inhibitors reported in the literature to date have been comprehensively listed out and described in detail. Moreover, the molecular mechanisms by which the Bcl-2 family proteins modulate the apoptotic processes and strategies for designing antagonists to anti-apoptotic proteins have been concisely discussed.
癌细胞逃避凋亡，而凋亡在内在途径中由Bcl-2家族蛋白调控。文献中已报道了许多凋亡蛋白以及与小分子/肽/蛋白结合的蛋白的实验性三维（3D）结构。在这篇综述文章中，全面列出并详细描述了迄今为止文献中报道的来自智人的Bcl-2家族蛋白的3D结构以及与小分子抑制剂结合的抗凋亡蛋白的复杂结构。此外，还简要讨论了Bcl-2家族蛋白调节凋亡过程的分子机制以及设计抗凋亡蛋白拮抗剂的策略。
