Ando Masaru, Miyazaki Eishi, Hatano Yutaka, Nishio Suehiro, Torigoe Chihiro, Yamasue Mari, Mukai Yutaka, Nureki Shin-Ichi, Kadota Jun-Ichi
Department of Respiratory Medicine and Infectious Diseases, Oita University, Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.
Center for Community Medicine, Oita University, Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan.
Clin Rheumatol. 2016 Sep;35(9):2277-81. doi: 10.1007/s10067-016-3356-0. Epub 2016 Jul 23.
Subcutaneous sarcoidosis is the specific subset of cutaneous sarcoidosis frequently associated with systemic disease. However, the disease activity, severity, and prognosis have not yet been elucidated due to the limited number of reported cases. The purpose of this study was to identify the clinical, laboratory, and prognostic differences between subcutaneous sarcoidosis and other type of cutaneous sarcoidosis. All patients with sarcoidosis diagnosed histopathologically from 2000 to 2012 at our institution were enrolled. The clinical, laboratory, chest X-ray, and pulmonary function test results were retrospectively evaluated in the patients with cutaneous sarcoidosis. In the 130 patients with sarcoidosis, cutaneous sarcoidosis was diagnosed in 37 patients (28.4 %), and 9 (6.9 %) of these patients had subcutaneous sarcoidosis. The serum levels of soluble interleukin-2 receptor (sIL-2R) were significantly elevated in the group of patients with subcutaneous sarcoidosis in comparison to the patients with other types of cutaneous sarcoidosis, whereas there was no significant difference in the severity score between the two groups. Following a 2-year observation period, three patients were in remission, five patients demonstrated stable disease, and one patient had progressive disease. Subcutaneous sarcoidosis may be associated with the disease activity, although it was not found to be associated with the disease severity and it was not a predictive factor for the prognosis. Furthermore, the prevalence of subcutaneous sarcoidosis may be higher than that in previously reported series.
皮下结节病是皮肤结节病的一个特定子集，常与全身性疾病相关。然而，由于报告病例数量有限，该病的活动度、严重程度和预后尚未阐明。本研究的目的是确定皮下结节病与其他类型皮肤结节病在临床、实验室检查及预后方面的差异。纳入了2000年至2012年在我院经组织病理学诊断为结节病的所有患者。对皮肤结节病患者的临床、实验室检查、胸部X线及肺功能检查结果进行回顾性评估。在130例结节病患者中，37例（28.4%）诊断为皮肤结节病，其中9例（6.9%）为皮下结节病。与其他类型皮肤结节病患者相比，皮下结节病患者组血清可溶性白细胞介素-2受体（sIL-2R）水平显著升高，而两组间严重程度评分无显著差异。经过2年的观察期，3例患者缓解，5例病情稳定，1例病情进展。皮下结节病可能与疾病活动度相关，尽管未发现其与疾病严重程度相关，也不是预后的预测因素。此外，皮下结节病的患病率可能高于先前报道的系列研究。
