Section of Dermatology and Venereology, Department of Medicine, University of Verona, Piazzale A. Stefani 1, Verona, Italy.
Clin Rheumatol. 2011 Aug;30(8):1123-8. doi: 10.1007/s10067-011-1731-4. Epub 2011 Apr 2.
Sarcoidosis is a multisystemic disease with cutaneous lesions present in about one fourth of patients. Cutaneous lesions may be specific or nonspecific based on the presence or the absence of sarcoidal granulomas. Subcutaneos sarcoidosis is the less frequent of the specific cutaneous lesions of sarcoidosis. We report here 2 new cases and review 83 cases reported in literature of subcutaneous sarcoidosis. Subcutaneous sarcoidosis present usually with asymptomatic firm nodules covered by normal-appearing skin, mostly on the forearms and legs. Diagnosis may require a high index of suspicion. In the vast majority of patients, subcutaneous nodules were the manifestation that allowed the diagnosis of systemic sarcoidosis. There is a strong association between subcutaneous sarcoidosis and bilateral hilar lymphadenopathy (72.7%). About 15% of patients have in order of frequency uveitis, parotitis, arthritis, mucositis, dactylitis, neurological and renal involvement, hepatosplenomegaly.
结节病是一种多系统疾病，约有四分之一的患者存在皮肤损伤。根据是否存在结节病肉芽肿，皮肤损伤可以是特异性的或非特异性的。皮下结节病是结节病特异性皮肤损伤中较少见的一种。我们在此报告 2 例新病例，并复习了文献中报道的 83 例皮下结节病。皮下结节病通常表现为无症状的坚实结节，覆盖正常皮肤，主要发生在前臂和腿部。诊断可能需要高度怀疑。在绝大多数患者中，皮下结节是诊断系统性结节病的表现。皮下结节病与双侧肺门淋巴结肿大（72.7%）之间存在很强的关联。约 15%的患者依次出现葡萄膜炎、腮腺炎、关节炎、黏膜炎、指（趾）炎、神经和肾脏受累、肝脾肿大。
