Huang Pinxiu, Wei Lihong, Li Xinlin
a Department of Reproductive Medicine , Liuzhou Maternity and Child Healthcare Hospital , Guangxi , China.
Gynecol Endocrinol. 2017 Jan;33(1):67-69. doi: 10.1080/09513590.2016.1207164. Epub 2016 Jul 22.
To investigate the effect of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer (FET) after two or more implantation failures (TIFs).
The study was a prospective randomized single-blind study of 161 cycles in patients undergoing FET who had TIFs. The intervention group received an intrauterine injection of 1000 IU of hCG before embryo transfer (ET) (n = 62). A placebo group (n = 49) received an intrauterine injection of physiological saline before ET. A control group (n = 50) did not receive an intrauterine injection. Clinical pregnancy rates, abortion rates, and ongoing pregnancy rates were compared between the three groups.
The clinical pregnancy rates were 59.68%, 53.06%, and 32.00% in the hCG group, placebo group, and control group, respectively. The clinical pregnancy rates were significantly higher in the hCG and placebo groups than in the control group. There were no significant differences in the abortion rates among the three groups.
An intrauterine administration of hCG before FET significantly improved the pregnancy rates after TIFs. But local injury caused by the operation of intrauterine perfusion may play an important role in improving clinical pregnancy rates.
探讨在经历两次或更多次种植失败（TIFs）后，冻融胚胎移植（FET）前宫腔内注射人绒毛膜促性腺激素（hCG）的效果。
本研究是一项针对161个FET周期且有TIFs的患者的前瞻性随机单盲研究。干预组在胚胎移植（ET）前接受1000 IU hCG的宫腔内注射（n = 62）。安慰剂组（n = 49）在ET前接受宫腔内生理盐水注射。对照组（n = 50）不接受宫腔内注射。比较三组的临床妊娠率、流产率和持续妊娠率。
hCG组、安慰剂组和对照组的临床妊娠率分别为59.68%、53.06%和32.00%。hCG组和安慰剂组的临床妊娠率显著高于对照组。三组间流产率无显著差异。
FET前宫腔内注射hCG可显著提高TIFs后的妊娠率。但宫腔灌注操作引起的局部损伤可能在提高临床妊娠率中起重要作用。
