Guangxi Medical University, Nanning, China.
Reproductive Medicine Center, Liuzhou Maternal and Child Healthcare Hospital, Liuzhou, China.
Am J Reprod Immunol. 2018 Feb;79(2). doi: 10.1111/aji.12809. Epub 2017 Dec 30.
The aim of this research was to investigate the effects of the intrauterine perfusion of hCG before a frozen-thawed embryo transfer (FET) in women with different implantation failure numbers.
This was a retrospective analysis of patients undergoing FET who received an intrauterine injection hCG 1000 IU before embryo transfer. The groups included women with their first implantation failure (A group, n = 26), second implantation failure (B group, n = 122), and three or more failures (C group, n = 77). Corresponding control groups (no infusion) were also included. The pregnancy rates were compared among these groups.
After intrauterine injection hCG, the biochemical pregnancy rates were 92.30%, 63.11%, 49.02%, and the clinical pregnancy rates were 76.92%, 54.91%, 48.05%, in the A, B, and C groups, respectively. The biochemical and clinical pregnancy rates were significantly higher in the A group than in the other groups (P < .05). The clinical pregnancy rates of the A and C groups were significantly higher than in the corresponding (no infusion) control groups (76.92% vs 56.81% and 48.05% vs 33.33%, P < .05).
Pregnancy rates decreased with the number of transplant failures. The intrauterine administration of hCG before FET significantly improved the pregnancy rates, especially after one and three or more implantation failures.
本研究旨在探讨在冻融胚胎移植（FET）前宫腔内注射 hCG 对不同着床失败次数的女性的影响。
这是一项对接受 FET 且胚胎移植前宫腔内注射 1000IU hCG 的患者进行的回顾性分析。研究组包括首次着床失败的患者（A 组，n=26）、第二次着床失败的患者（B 组，n=122）和三次或更多次失败的患者（C 组，n=77）。还包括相应的对照组（未输注）。比较这些组之间的妊娠率。
宫腔内注射 hCG 后，A、B 和 C 组的生化妊娠率分别为 92.30%、63.11%和 49.02%，临床妊娠率分别为 76.92%、54.91%和 48.05%。A 组的生化和临床妊娠率明显高于其他组（P<0.05）。A 组和 C 组的临床妊娠率明显高于相应的对照组（76.92%比 56.81%和 48.05%比 33.33%，P<0.05）。
移植失败次数越多，妊娠率越低。FET 前宫腔内注射 hCG 可显著提高妊娠率，尤其是在一次或三次以上着床失败后。
