Cho K J, Fanders B, Smid A, McLaughlin P
Department of Radiology, University of Michigan, Ann Arbor.
Invest Radiol. 1989 May;24(5):371-4. doi: 10.1097/00004424-198905000-00007.
The authors used new fibrous collagen embolic material (5 by 75 microns in size) for flow-directed hepatic artery embolization in four rabbits; the purpose of the study was to examine the acute effects of the material on hepatic microcirculation. Extent of hepatic dearterialization, level of arterial occlusion, collateral formation and status of portal sinusoidal perfusion were evaluated under a dissection microscope after embolization. The collagen material produced proximal and peripheral hepatic arterial occlusion with complete hepatic dearterialization, including the bile duct. Portal sinusoidal perfusion appeared to be intact. No intrahepatic microcollaterals were observed.
作者使用了新型纤维状胶原栓塞材料（尺寸为5×75微米）对4只兔子进行血流导向性肝动脉栓塞；该研究的目的是检查该材料对肝脏微循环的急性影响。栓塞后，在解剖显微镜下评估肝动脉去血管化程度、动脉闭塞水平、侧支形成情况以及门静脉窦灌注状态。胶原材料导致肝动脉近端和周边闭塞，包括胆管在内的肝脏完全去血管化。门静脉窦灌注似乎完好无损。未观察到肝内微侧支。
