尼泊尔疑似患结核病大象与健康大象的皮质醇和甲状腺激素比较。
Comparison of cortisol and thyroid hormones between tuberculosis-suspect and healthy elephants of Nepal.
作者信息
Paudel Sarad, Brown Janine L, Thapaliya Sharada, Dhakal Ishwari P, Mikota Susan K, Gairhe Kamal P, Shimozuru Michito, Tsubota Toshio
机构信息
Laboratory of Wildlife Biology and Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan.
出版信息
J Vet Med Sci. 2016 Dec 1;78(11):1713-1716. doi: 10.1292/jvms.16-0212. Epub 2016 Jul 23.
We compared cortisol and thyroid hormone (T3 and T4) concentrations between tuberculosis (TB)-suspected (n=10) and healthy (n=10) elephants of Nepal. Whole blood was collected from captive elephants throughout Nepal, and TB testing was performed using the ElephantTB STAT-PAK and DPP VetTB serological assays that detect antibodies against Mycobacterium tuberculosis and M. bovis in elephant serum. Cortisol, T3 and T4 were quantified by competitive enzyme immunoassays, and the results showed no significant differences in hormone concentrations between TB-suspect and healthy elephants. These preliminary data suggest neither adrenal nor thyroid function is altered by TB disease status. However, more elephants, including those positively diagnosed for TB by trunk wash cultures, need to be evaluated over time to confirm results.
我们比较了尼泊尔疑似患结核病（TB）的大象（n = 10）和健康大象（n = 10）的皮质醇和甲状腺激素（T3和T4）浓度。从尼泊尔各地圈养的大象身上采集全血，并使用ElephantTB STAT-PAK和DPP VetTB血清学检测方法进行结核病检测，这些检测方法可检测大象血清中抗结核分枝杆菌和牛分枝杆菌的抗体。通过竞争性酶免疫测定法定量皮质醇、T3和T4，结果显示疑似患结核病的大象和健康大象的激素浓度没有显著差异。这些初步数据表明，结核病状态不会改变肾上腺或甲状腺功能。然而，随着时间的推移，需要对更多的大象进行评估，包括那些通过象鼻冲洗培养确诊为结核病阳性的大象，以确认结果。
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