Guo Zhenming, Niu Weibo, Bi Yan, Zhang Rui, Ren Decheng, Hu Jiaxin, Huang Xiaoye, Wu Xi, Cao Yanfei, Yang Fengping, Wang Lu, Li Weidong, Li Xingwang, Xu Yifeng, He Lin, Yu Tao, He Guang
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, 600 South Wan Ping Road, Shanghai 200030, PR China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, 600 South Wan Ping Road, Shanghai 200030, PR China.
Neurosci Lett. 2016 Sep 6;630:132-135. doi: 10.1016/j.neulet.2016.07.038. Epub 2016 Jul 21.
Schizophrenia is a severe and complex mental disorder with high heritability. There is evidence that mutations in the gene of Nmethyl-d-aspartate-type glutamate receptors (NMDAR) are associated with schizophrenia. GRIN2B encodes a subunit of NMDARs, and has been identified as a candidate gene for many psychiatric disorders, especially schizophrenia. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRIN2B were associated with schizophrenia. Four SNPs (rs890, rs1806191, rs219872, rs172677) were genotyped in 752 schizophrenic patients and 846 healthy controls of the Chinese Han population. Our results indicate differences in allele and genotype frequencies of rs890 between case and control. These results were assessed by adapting different genetic models (codominant, dominant, recessive, overdominant, log-additive models). After controlling for confounding factors including sex and age, rs890 remained associated with schizophrenia. In addition, rs890 and rs1806191 were found to form a haplotype associated with schizophrenia. In summary, our results indicate that the GRIN2B SNP rs890 might be associated with schizophrenia in the Chinese Han population.
精神分裂症是一种严重且复杂的遗传性精神障碍。有证据表明，N-甲基-D-天冬氨酸型谷氨酸受体（NMDAR）基因的突变与精神分裂症有关。GRIN2B编码NMDAR的一个亚基，并且已被确定为许多精神疾病尤其是精神分裂症的候选基因。在本研究中，我们调查了GRIN2B中的单核苷酸多态性（SNP）是否与精神分裂症有关。对752例中国汉族精神分裂症患者和846例健康对照者的四个SNP（rs890、rs1806191、rs219872、rs172677）进行了基因分型。我们的结果表明，病例组和对照组之间rs890的等位基因和基因型频率存在差异。通过采用不同的遗传模型（共显性、显性、隐性、超显性、对数加性模型）对这些结果进行了评估。在控制了包括性别和年龄在内的混杂因素后，rs890仍与精神分裂症有关。此外，发现rs890和rs1806191形成了一种与精神分裂症相关的单倍型。总之，我们的结果表明，GRIN2B SNP rs890可能与中国汉族人群的精神分裂症有关。
