前列腺癌的展开组学：关于内在无序蛋白在前列腺癌中的丰度及作用
Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer.
作者信息
Landau Kevin S, Na Insung, Schenck Ryan O, Uversky Vladimir N
机构信息
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia, .
出版信息
Asian J Androl. 2016 Sep-Oct;18(5):662-72. doi: 10.4103/1008-682X.184999.
Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.
前列腺癌和良性前列腺增生等前列腺疾病在男性中极为普遍。针对内在无序蛋白质在前列腺癌中的丰度和作用的研究数量相当有限。本研究的目的是分析先前与前列腺癌发病机制相关的蛋白质的无序患病率和程度，并将这些蛋白质与整个人类蛋白质组进行比较。对这些数据集的分析为得出无序蛋白质在这种常见男性疾病中的作用的结论提供了方法。我们还希望我们的分析结果可能会引发对这些蛋白质的未来实验研究，以找到与这种疾病相关的新途径。
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