Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ageing Res Rev. 2016 Nov;31:55-66. doi: 10.1016/j.arr.2016.07.004. Epub 2016 Jul 21.
Current ageing research is aimed not only at the promotion of longevity, but also at improving health span through the discovery and development of new therapeutic strategies by investigating molecular and cellular pathways involved in cellular senescence. Understanding the mechanism of action of polyphenolic compounds targeting mTOR (mechanistic target of rapamycin) and related pathways opens up new directions to revolutionize ways to slow down the onset and development of age-dependent degeneration. Herein, we will discuss the mechanisms by which polyphenols can delay the molecular pathogenesis of ageing via manipulation or more specifically inhibition of mTOR-signaling pathways. We will also discuss the implications of polyphenols in targeting mTOR and its related pathways on health life span extension and longevity..
目前的衰老研究不仅旨在促进长寿，还通过研究参与细胞衰老的分子和细胞途径，发现和开发新的治疗策略，来提高健康寿命。通过了解针对 mTOR（雷帕霉素的作用靶点）和相关途径的多酚化合物的作用机制，为彻底改变减缓与年龄相关的退化的方法开辟了新的方向。在此，我们将讨论多酚类物质通过操纵或更具体地抑制 mTOR 信号通路来延迟衰老的分子发病机制的机制。我们还将讨论多酚类物质在靶向 mTOR 及其相关途径以延长健康寿命和延长寿命方面的意义。
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