Blagosklonny Mikhail V
Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Oncotarget. 2017 May 30;8(22):35492-35507. doi: 10.18632/oncotarget.18033.
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.
mTOR抑制剂，包括临床上可用的雷帕霉素类似物，如雷帕霉素（西罗莫司）和依维莫司，是衰老抑制剂，可抑制细胞衰老。雷帕霉素可延缓多种物种（从蠕虫到哺乳动物）的衰老并延长寿命。雷帕霉素类似物可预防与年龄相关的疾病，包括癌症、动脉粥样硬化、肥胖症、神经退行性变和视网膜病变，并有可能使干细胞、免疫力和新陈代谢恢复活力。在此，我进一步提出雷帕霉素如何与二甲双胍、血管紧张素II信号传导抑制剂（氯沙坦、赖诺普利）、他汀类药物（辛伐他汀、阿托伐他汀）、普萘洛尔、阿司匹林和一种磷酸二酯酶5抑制剂联合使用。这些药物与体育锻炼和抗衰老饮食（科斯切伊配方）的合理组合可使其抗衰老效果最大化并减少副作用。
