Cairo Francesco, Pagliaro Umberto, Buti Jacopo, Baccini Michela, Graziani Filippo, Tonelli Paolo, Pagavino Gabriella, Tonetti Maurizio S
Section of Periodontology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Private Practice, Florence, Italy.
J Clin Periodontol. 2016 Nov;43(11):965-975. doi: 10.1111/jcpe.12603. Epub 2016 Sep 16.
The aim of this study was to perform a systematic review (SR) of randomized controlled trials (RCTs) to explore if periodontal plastic surgery procedures for the treatment of single and multiple gingival recessions (Rec) may improve aesthetics at patient and professional levels.
In order to combine evidence from direct and indirect comparisons by different trials a Bayesian network meta-analysis (BNM) was planned. A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until January 2016 was conducted to identify RCTs presenting aesthetic outcomes after root coverage using standardized evaluations at patient and professional level.
A total of 16 RCTs were selected in the SR; three RTCs presenting professional aesthetic evaluation with Root coverage Aesthetic Score (RES) and three showing final self-perception using the Visual Analogue Scale (VAS Est) could be included in a BNM model. Coronally Advanced Flap plus Connective Tissue Graft (CAF + CTG) and CAF + Acellular Dermal Matrix (ADM) and Autologous Fibroblasts (AF) were associated with the best RES outcomes (best probability = 24% and 64%, respectively), while CAF + CTG and CAF + CTG + Enamel matrix Derivatives (EMD) obtained highest values of VAS Est score (best probability = 44% and 26%, respectively).
Periodontal Plastic Surgery (PPS) techniques applying grafts underneath CAF with or without the adding of EMD are associated with improved aesthetics assessed by final patient perception and RES as professional evaluation system.
本研究旨在对随机对照试验(RCT)进行系统评价(SR),以探讨用于治疗单个和多个牙龈退缩(Rec)的牙周整形手术是否能在患者和专业层面改善美观度。
为了整合不同试验的直接和间接比较证据,计划进行贝叶斯网络荟萃分析(BNM)。在PubMed、Cochrane图书馆、EMBASE以及截至2016年1月手工检索的期刊上进行文献检索,以识别使用患者和专业层面标准化评估的、呈现根面覆盖后美学结果的RCT。
在系统评价中总共选择了16项RCT;三项使用根面覆盖美学评分(RES)进行专业美学评估的随机对照试验以及三项使用视觉模拟量表(VAS Est)显示最终自我认知的试验可纳入BNM模型。冠向复位瓣联合结缔组织移植(CAF + CTG)、CAF联合无细胞真皮基质(ADM)和自体成纤维细胞(AF)与最佳RES结果相关(最佳概率分别为24%和64%),而CAF + CTG和CAF + CTG +釉基质衍生物(EMD)获得了最高的VAS Est评分值(最佳概率分别为44%和26%)。
在CAF下方应用移植物,无论是否添加EMD的牙周整形手术(PPS)技术,与通过最终患者感知和作为专业评估系统的RES评估的美观度改善相关。