[维吾尔族人群中GCKR基因多态性与2型糖尿病的关联]

[Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs].

作者信息

Ma Qi, Wang Li, Yao Hua, Zhu Jun, Wang Shuxia, Zhang Xhaoxia, Wang Tingting, Ma Yan, Su Yinxia, Wang Zhiqiang, Ding Lili

机构信息

Xinjiang Key Laboratory of Metabolic Disease, Clinical Medical Research Institute, Department of Endocrinology, Department of Health Management and Health Check, Department of Laboratory Medicine, Department of Infection Control, First Affiliated Hospital, Department of Maternal, Child and Adolescent Health, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830054, China. Email:

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Aug;33(4):540-4. doi: 10.3760/cma.j.issn.1003-9406.2016.04.026.

DOI:10.3760/cma.j.issn.1003-9406.2016.04.026

PMID:27455017

Abstract

OBJECTIVE

To assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China.

METHODS

One thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system.

RESULTS

The distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups (P>0.05). After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model (OR=1.181, 95%CI: 1.021-1.366, P=0.025; OR=1.296, 95%CI: 1.043-1.610, P=0.019). The total cholesterol level was higher in AA carriers than GG and GA carriers (P<0.05).

CONCLUSION

The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.

摘要

目的

评估中国新疆维吾尔族人群中葡萄糖激酶调节蛋白（GCKR）基因多态性与2型糖尿病（T2D）的关联。

方法

招募了1006例T2D患者和1004例健康对照。采用Sequenom Mass ARRAY系统测定GCKR基因的rs780094基因型。

结果

两组间GCKR rs780094的AA、AG和GG基因型分布无统计学差异（P>0.05）。调整混杂因素后，在加性和显性模型中观察到rs780094与T2D有关联（OR=1.181，95%CI：1.021-1.366，P=0.025；OR=1.296，95%CI：1.043-1.610，P=0.019）。AA携带者的总胆固醇水平高于GG和GA携带者（P<0.05）。