Crincoli Vito, Fatone Laura, Fanelli Margherita, Rotolo Rossana Patricia, Chialà Angela, Favia Gianfranco, Lapadula Giovanni
Complex Operating Unit of Odontostomatology, Interdisciplinary Department of Medicine, "Aldo Moro" University of Bari., Piazza Giulio Cesare 11, 70124 Bari, Italy.
Complex Operating Unit of Nuclear Medicine-Medical Statistics, Interdisciplinary Department of Medicine, "Aldo Moro" University of Bari., Piazza Giulio Cesare 11, 70124 Bari, Italy.
Int J Mol Sci. 2016 Jul 22;17(7):1189. doi: 10.3390/ijms17071189.
Scleroderma is a disorder involving oral and facial tissues, with skin hardening, thin lips, deep wrinkles, xerostomia, tongue rigidity, and microstomia. The aim of this study was to investigate the prevalence of oral manifestations and temporomandibular disorders (TMD) in Systemic Sclerosis (SSc) patients compared with healthy people. Eighty patients (6 men, 74 women) fulfilling ACR/EULAR SSc Criteria were enrolled. A randomly selected group of 80 patients, matched by sex and age served as control group. The examination for TMD signs and symptoms was based on the standardized Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) through a questionnaire and clinical examination. SSc patients complained more frequently (78.8%) of oral symptoms (Xerostomia, dysgeusia, dysphagia and stomatodynia) than controls (28.7%) (χ² = 40.23 p = 0.001). TMD symptoms (muscle pain on chewing, difficulty in mouth opening, headaches) were complained by 92.5% of SSc patients and by 76.2% of controls (χ² = 8.012 p = 0.005). At the clinical examination, 85% of SSc patients showed restricted opening versus 20.0% of controls (χ² = 67.77 p = 0.001), 81.2% of SSc showed reduced right lateral excursion versus 50% of controls (χ² = 17.316 p = 0.001); 73.8% of SSc showed limited left lateral excursion versus 53.8% of controls (χ² = 6.924 p = 0.009); and 73.8% of SSc had narrow protrusion versus 56.2% of controls (χ² = 5.385 p = 0.02).
硬皮病是一种累及口腔和面部组织的疾病，表现为皮肤硬化、嘴唇变薄、皱纹加深、口干、舌僵和小口症。本研究的目的是调查系统性硬化症（SSc）患者与健康人相比口腔表现和颞下颌关节紊乱（TMD）的患病率。纳入了80例符合美国风湿病学会/欧洲抗风湿病联盟SSc标准的患者（6例男性，74例女性）。随机选择一组80例按性别和年龄匹配的患者作为对照组。通过问卷和临床检查，依据颞下颌关节紊乱的标准化研究诊断标准（RDC/TMD）对TMD体征和症状进行检查。SSc患者比对照组（28.7%）更频繁地抱怨口腔症状（口干、味觉障碍、吞咽困难和口腔疼痛）（78.8%）（χ² = 40.23，p = 0.001）。92.5%的SSc患者抱怨有TMD症状（咀嚼时肌肉疼痛、张口困难、头痛），而对照组为76.2%（χ² = 8.012，p = 0.005）。在临床检查中，85%的SSc患者开口受限，而对照组为20.0%（χ² = 67.77，p = 0.001）；81.2%的SSc患者右侧侧方运动减少，而对照组为50%（χ² = 17.316，p = 0.001）；73.8%的SSc患者左侧侧方运动受限，而对照组为53.8%（χ² = 6.924，p = 0.009）；73.8%的SSc患者前伸受限，而对照组为56.2%（χ² = 5.385，p = 0.02）。
