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The step-and-shoot IMRT overshooting phenomenon: a novel method to mitigate patient overdosage.

作者信息

Zhen Heming, Ouyang Luo, Bao Qinan, Qin Nan, Stojadinovic Strahinja, Pompos Arnold

机构信息

Rush University Medical Center.

出版信息

J Appl Clin Med Phys. 2016 Jul 8;17(4):214-222. doi: 10.1120/jacmp.v17i4.6101.

DOI:10.1120/jacmp.v17i4.6101
PMID:27455482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5690057/
Abstract

The goal of this work is to evaluate the dosimetric impact of an overshooting phenomenon in step-and-shoot IMRT delivery, and to demonstrate a novel method to mitigate the issue. Five pelvis IMRT patients treated on Varian 2100C EX linacs with larger than +4.5% phantom ion chamber point-dose difference relative to planned dose were investigated. For each patient plan, 5 fractions were delivered. DynaLog files were recorded and centi-MU pulses from dose integrator board for every control point (CP) were counted using a commercial pulse counter. The counter recorded CP MU agrees with DynaLog records, both showing an ~ 0.6MU overshoot of the first segment of every beam. The 3D patient dose was recalculated from the counter records and compared to the planned dose, showing that the overshoot resulted in on average 2.05% of PTV D95 error, and 2.49%, 2.61% and 2.45% of D1cc error for rectum, bladder, and bowel, respectively. The initial plans were then modified by inserting a specially designed MLC segment to the start of every beam. The modified plans were also delivered five times. The dose from the modified delivery was calculated using counter recorded CP MU. The corresponding Dx parameters were all within 0.31% from the original plan. IMRT QA results also show a 2.2% improvement in ion chamber point-dose agreement. The results demonstrate that the proposed plan modification method effectively eliminates the overdosage from the overshooting phenomenon.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/9c83facbbbe0/ACM2-17-214-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/15411c1b0268/ACM2-17-214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/ab263e2ac834/ACM2-17-214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/9c83facbbbe0/ACM2-17-214-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/15411c1b0268/ACM2-17-214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/ab263e2ac834/ACM2-17-214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cc1/5690057/9c83facbbbe0/ACM2-17-214-g003.jpg

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本文引用的文献

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Monte Carlo based, patient-specific RapidArc QA using Linac log files.基于蒙特卡罗的、针对患者的 RapidArc QA 使用 Linac 日志文件。
Med Phys. 2010 Jan;37(1):116-23. doi: 10.1118/1.3266821.
2
Monte Carlo based IMRT dose verification using MLC log files and R/V outputs.基于蒙特卡罗方法,利用多叶准直器日志文件和R/V输出进行调强放射治疗剂量验证。
Med Phys. 2006 Jul;33(7):2557-64. doi: 10.1118/1.2208916.
3
Improving delivery of segments with small MU in step-and-shoot IMRT.在静态调强放射治疗中提高小MU射野的剂量输出
Med Phys. 2006 Apr;33(4):1067-73. doi: 10.1118/1.2174128.
4
Dosimetry limitations and a dose correction methodology for step-and-shoot IMRT.步进式调强放射治疗的剂量测定局限性及剂量校正方法
Phys Med Biol. 2006 Feb 7;51(3):637-52. doi: 10.1088/0031-9155/51/3/011. Epub 2006 Jan 19.
5
An extensive log-file analysis of step-and-shoot intensity modulated radiation therapy segment delivery errors.步进式调强放射治疗射野剂量输送误差的广泛日志文件分析
Med Phys. 2004 Jun;31(6):1593-602. doi: 10.1118/1.1751011.
6
Verification of dynamic and segmental IMRT delivery by dynamic log file analysis.
J Appl Clin Med Phys. 2002 Spring;3(2):63-72. doi: 10.1120/jacmp.v3i2.2578.
7
Communication and sampling rate limitations in IMRT delivery with a dynamic multileaf collimator system.
Med Phys. 2002 Mar;29(3):412-23. doi: 10.1118/1.1449496.
8
The overshoot phenomenon in step-and-shoot IMRT delivery.步进式调强放疗(IMRT)治疗中的剂量超射现象。
J Appl Clin Med Phys. 2001 Summer;2(3):138-48. doi: 10.1120/jacmp.v2i3.2607.