Department of Chemistry, The University of Texas at San Antonio , One UTSA Circle, San Antonio, Texas 78249, United States.
Org Lett. 2016 Aug 19;18(16):3937-9. doi: 10.1021/acs.orglett.6b01904. Epub 2016 Jul 26.
A mild catalytic synthesis of alkynes via a tandem Pd-catalyzed decarboxylation/elimination of enol triflates is described. Key attributes of the method include readily available starting materials, broad functional group tolerance, and the ability to access terminal, internal, and halogenated alkynes. The preliminary scope of the reaction is demonstrated on 25 different examples with yields ranging from 63% to 96%.
本文描述了一种通过 Pd 催化的脱羧/消除烯醇三氟甲磺酸酯的串联反应温和催化合成炔烃的方法。该方法的关键特点包括易得的起始原料、广泛的官能团耐受性以及能够获得末端、内部和卤代炔烃的能力。该反应的初步范围在 25 个不同的实例中得到了证明，产率范围从 63%到 96%不等。
