Friedman Alexander M, Ananth Cande V, Huang Yongmei, D'Alton Mary E, Wright Jason D
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, NY.
Am J Obstet Gynecol. 2016 Dec;215(6):795.e1-795.e14. doi: 10.1016/j.ajog.2016.07.039. Epub 2016 Jul 22.
In the setting of persistently high risk for maternal death and severe obstetric morbidity, little is known about the relationship between hospital delivery volume and maternal outcomes.
The objectives of this analysis were (1) to determine maternal risk for severe morbidity during delivery hospitalizations by hospital delivery volume in the United States and (2) to characterize, by hospital volume, the risk for death in the setting of severe obstetric morbidity, a concept known as failure to rescue.
This cohort study evaluated 50,433,539 delivery hospitalizations across the United States from 1998-2010. The main outcome measures were (1) severe morbidity that was defined as a composite of any 1 of 15 diagnoses that are representative of acute organ injury and critical illness and (2) failure to rescue that was defined as death in the setting of severe morbidity.
The prevalence of severe morbidity rose from 471.2-751.5 cases per 100,000 deliveries from 1998-2010, which was an increase of 59.5%. Failure to rescue was highest in 1998 (1.5%), decreased to 0.6% in 2007, and rose to 0.9% in 2010. In models that were adjusted for comorbid risk and hospital factors, both low and high annualized delivery volume were associated with increased risk for failure to rescue and severe morbidity. However, the relative importance of hospital volume for both outcomes compared with other factors was relatively small.
Although low-and high-delivery volume are associated with increased risk for both failure to rescue and severe maternal morbidity, other factors, in particular characteristics of individual centers, may be more important in the determination of outcomes.
在孕产妇死亡和严重产科并发症风险持续居高不下的情况下,关于医院分娩量与孕产妇结局之间的关系,人们了解甚少。
本分析的目的是:(1)根据美国医院的分娩量确定分娩住院期间严重并发症的孕产妇风险;(2)按医院规模描述严重产科并发症情况下的死亡风险,即所谓的“救援失败”概念。
这项队列研究评估了1998年至2010年美国50433539例分娩住院病例。主要结局指标为:(1)严重并发症,定义为代表急性器官损伤和危重病的15种诊断中任何一种的综合情况;(2)救援失败,定义为严重并发症情况下的死亡。
1998年至2010年,严重并发症的患病率从每10万例分娩471.2例增至751.5例,增幅为59.5%。救援失败率在1998年最高(1.5%),2007年降至0.6%,2010年升至0.9%。在对合并症风险和医院因素进行调整的模型中,低年分娩量和高年分娩量均与救援失败和严重并发症风险增加相关。然而,与其他因素相比,医院规模对这两种结局的相对重要性相对较小。
尽管低分娩量和高分娩量都与救援失败和严重孕产妇并发症风险增加相关,但其他因素,特别是各个中心的特征,在结局的决定中可能更为重要。