Pece Alfredo, Allegrini Davide, Kontadakis Stelios, Querques Giuseppe, Rossetti Luca
Department of Ophthalmology, Melegnano Hospital, Via Pandina 1, 20077 Vizzolo Predabissi, Milan, Italy.
University Paris XII, Creteil, France.
BMC Ophthalmol. 2016 Jul 26;16:122. doi: 10.1186/s12886-016-0307-0.
To report a patient with angioid streaks (ASs) and coincident multiple evanescent white dot syndrome (MEWDS) who developed choroidal neovascularization (CNV).
A 20-year-old woman presented with reduced vision (20/100) in her left eye (LE). Based on a complete ophthalmologic examination the patient was diagnosed with ASs and coincident MEWDS. Two weeks later best-corrected visual acuity (BCVA) improved up to 20/25 and the MEWDS findings almost disappeared. Two months later BCVA dropped again (20/100) due to the development of CNV which was treated by a single intravitreal injection of ranibizumab (0.5 mg/0.05 mL). One month after this BCVA improved up to 20/40, and there was regression of the CNV. There was no need for retreatment at the last follow-up visit, 1 year after the ranibizumab injection, when the patient showed further recovery of BCVA up to 20/25.
In this case of ASs, MEWDS completely resolved after 2 weeks, but 2 months later CNV developed. A single intravitreal injection of ranibizumab had a long-lasting effect. Larger series are necessary to clarify the pathogenesis of CNV in such cases and the role of intravitreal ranibizumab.
报告一例患有血管样条纹（ASs）并合并多发性一过性白点综合征（MEWDS）且发生脉络膜新生血管（CNV）的患者。
一名20岁女性左眼视力下降（20/100）。经过全面的眼科检查，该患者被诊断为ASs并合并MEWDS。两周后，最佳矫正视力（BCVA）提高到20/25，MEWDS的表现几乎消失。两个月后，由于CNV的发生，BCVA再次下降（20/100），通过玻璃体内单次注射雷珠单抗（0.5mg/0.05mL）进行治疗。注射后一个月，BCVA提高到20/40，CNV有所消退。在雷珠单抗注射1年后的最后一次随访中，患者无需再次治疗，此时BCVA进一步恢复到20/25。
在该ASs病例中，MEWDS在2周后完全消退，但2个月后发生了CNV。玻璃体内单次注射雷珠单抗具有持久的效果。需要更大规模的系列研究来阐明此类病例中CNV的发病机制以及玻璃体内雷珠单抗的作用。
