Azevedo-Silva J, Queirós O, Baltazar F, Ułaszewski S, Goffeau A, Ko Y H, Pedersen P L, Preto A, Casal M
Centre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Portugal, Campus de Gualtar, 4710-057, Braga, Portugal.
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116, Gandra, PRD, Portugal.
J Bioenerg Biomembr. 2016 Aug;48(4):349-62. doi: 10.1007/s10863-016-9670-z. Epub 2016 Jul 25.
At the beginning of the twenty-first century, 3-bromopyruvate (3BP), a simple alkylating chemical compound was presented to the scientific community as a potent anticancer agent, able to cause rapid toxicity to cancer cells without bystander effects on normal tissues. The altered metabolism of cancers, an essential hallmark for their progression, also became their Achilles heel by facilitating 3BP's selective entry and specific targeting. Treatment with 3BP has been administered in several cancer type models both in vitro and in vivo, either alone or in combination with other anticancer therapeutic approaches. These studies clearly demonstrate 3BP's broad action against multiple cancer types. Clinical trials using 3BP are needed to further support its anticancer efficacy against multiple cancer types thus making it available to more than 30 million patients living with cancer worldwide. This review discusses current knowledge about 3BP related to cancer and discusses also the possibility of its use in future clinical applications as it relates to safety and treatment issues.
在21世纪初，3-溴丙酮酸（3BP），一种简单的烷基化化合物，作为一种有效的抗癌剂被介绍给科学界，它能够对癌细胞迅速产生毒性，而不会对正常组织产生旁观者效应。癌症代谢的改变是其进展的一个重要标志，也通过促进3BP的选择性进入和特异性靶向成为了它们的致命弱点。在多种癌症类型的体外和体内模型中，已经单独或与其他抗癌治疗方法联合使用3BP进行治疗。这些研究清楚地证明了3BP对多种癌症类型具有广泛的作用。需要进行使用3BP的临床试验，以进一步支持其对多种癌症类型的抗癌疗效，从而使全球超过3000万癌症患者能够使用它。这篇综述讨论了目前关于3BP与癌症相关的知识，并探讨了其在未来临床应用中的使用可能性，涉及安全性和治疗问题。
