Mattaini Katherine R, Sullivan Mark R, Vander Heiden Matthew G
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 Dana-Farber Cancer Institute, Boston, MA 02215 Broad Institute, Cambridge, MA 02139
J Cell Biol. 2016 Aug 1;214(3):249-57. doi: 10.1083/jcb.201604085. Epub 2016 Jul 25.
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer.
丝氨酸代谢在癌症中常常失调；然而，这赋予肿瘤的益处仍存在争议。在许多情况下，仅细胞外丝氨酸就足以支持癌细胞增殖，而一些癌细胞会增加从葡萄糖合成丝氨酸的过程，甚至在存在大量细胞外丝氨酸的情况下仍需要从头合成丝氨酸。最近的研究为丝氨酸代谢在癌症中的作用提供了新的线索，表明活跃的丝氨酸合成可能是以影响癌症的方式促进氨基酸转运、核苷酸合成、叶酸代谢和氧化还原稳态所必需的。
