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AMPKα1: SUMO Wrestling Runx2 as a Strategy to Inhibit Arteriosclerotic Calcification.

作者信息

Towler Dwight A

机构信息

From the Endocrine Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.

出版信息

Circ Res. 2016 Jul 22;119(3):398-400. doi: 10.1161/CIRCRESAHA.116.309237.

DOI:10.1161/CIRCRESAHA.116.309237
PMID:27458191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5051572/
Abstract
摘要

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Osteoporos Int. 2016 Nov;27(11):3279-3287. doi: 10.1007/s00198-016-3660-1. Epub 2016 Jun 21.
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Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo.腺苷一磷酸激活蛋白激酶 α1 在血管平滑肌细胞中的消融促进了饮食诱导的体内动脉粥样硬化钙化。
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Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148.Smurf1通过丝氨酸148抑制成骨细胞分化、骨形成和葡萄糖稳态。
Cell Rep. 2016 Apr 5;15(1):27-35. doi: 10.1016/j.celrep.2016.03.003. Epub 2016 Mar 24.
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Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease.2 型糖尿病伴微血管病变患者的皮质骨容积减少。
Eur J Endocrinol. 2016 Feb;174(2):115-24. doi: 10.1530/EJE-15-0860. Epub 2015 Nov 4.
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Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.LRP6-TCF7L2活性受损增强平滑肌细胞可塑性并导致冠状动脉疾病。
Cell Rep. 2015 Oct 27;13(4):746-759. doi: 10.1016/j.celrep.2015.09.028. Epub 2015 Oct 17.
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Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.血管平滑肌中的低密度脂蛋白受体相关蛋白6(LRP6)通过抑制非经典Wnt信号通路来限制糖尿病低密度脂蛋白受体基因敲除(LDLR-/-)小鼠的动脉粥样硬化钙化。
Circ Res. 2015 Jul 3;117(2):142-56. doi: 10.1161/CIRCRESAHA.117.306712. Epub 2015 Jun 1.
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