Hocking Jay, Mithraprabhu Sridurga, Kalff Anna, Spencer Andrew
Myeloma Research Group, Australian Center for Blood Diseases, Monash University, Melbourne 3004, Australia; Malignant Haematology & Stem Cell Transplantation Service, Alfred Hospital, Melbourne 3004, Australia.
Myeloma Research Group, Australian Center for Blood Diseases, Monash University, Melbourne 3004, Australia.
Cancer Biol Med. 2016 Jun;13(2):215-25. doi: 10.20892/j.issn.2095-3941.2016.0025.
Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment.
循环游离核酸,即游离DNA和循环微小RNA,在血液系统恶性肿瘤和实体恶性肿瘤患者的血浆中含量高于健康个体。在血液系统恶性肿瘤患者中,游离DNA反映了潜在的肿瘤突变谱,而微小RNA反映了肿瘤内部以及潜在的周围微环境和免疫效应细胞内的基因干扰机制。这些循环核酸提供了一种潜在的简单、非侵入性、可重复的分析方法,有助于癌症治疗中的诊断、预后评估和治疗决策。