在一名肝移植受者中，使用基于磷霉素的多药方案成功治疗广泛耐药肺炎克雷伯菌的播散性感染。
Successful treatment of a disseminated infection with extensively drug-resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin-based multidrug regimen.
作者信息
Mills J P, Wilck M B, Weikert B C, Porrett P M, Timko D, Alby K, Bonomo R A, Blumberg E A
机构信息
Division of Infectious Diseases, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Transpl Infect Dis. 2016 Oct;18(5):777-781. doi: 10.1111/tid.12578. Epub 2016 Sep 7.
Abstract
Donor-derived infections with multidrug-resistant gram-negative bacteria are associated with poor outcomes, in part because of limited treatment options. Here, we describe a case of donor-derived, disseminated infection with colistin-resistant, carbapenemase-producing Klebsiella pneumoniae in a liver transplant recipient that was cured with addition of intravenous fosfomycin to a multidrug regimen, in conjunction with aggressive surgical source control. Intravenous fosfomycin represents a promising adjunctive agent for use in treatment of extensively drug-resistant infections in immunocompromised hosts.
摘要
供体来源的耐多药革兰氏阴性菌感染与不良预后相关，部分原因是治疗选择有限。在此，我们描述了一例肝移植受者发生供体来源的、播散性耐黏菌素、产碳青霉烯酶肺炎克雷伯菌感染的病例，该病例通过在多药治疗方案中加用静脉注射磷霉素并结合积极的手术源头控制得以治愈。静脉注射磷霉素是一种有前景的辅助药物，可用于治疗免疫功能低下宿主的广泛耐药感染。
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