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"Double carbapenem" and oral fosfomycin for the treatment of complicated urinary tract infections caused by bla -harboring Enterobacteriaceae in kidney transplantation.“双碳青霉烯类”联合口服磷霉素治疗肾移植中携带bla的肠杆菌科细菌引起的复杂性尿路感染
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New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised.肠杆菌科细菌中的新德里金属β-内酰胺酶（NDM-1）：碳青霉烯类药物的治疗选择受到影响。
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fosfomycin susceptibility against carbapenem-resistant or extended-spectrum beta-lactamase-producing gram-negative fosfomycin-naive uropathogens: An alluring option or an illusion.磷霉素对耐碳青霉烯类或产超广谱β-内酰胺酶的初治革兰氏阴性尿路病原体的敏感性：诱人选择还是幻想。
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Double-carbapenem therapy in the treatment of multidrug resistant Gram-negative bacterial infections: a systematic review and meta-analysis.双联碳青霉烯类抗菌药物治疗多重耐药革兰阴性菌感染：系统评价和荟萃分析。
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The role of therapy with aminoglycoside in the outcomes of kidney transplant recipients infected with polymyxin- and carbapenem-resistant Enterobacteriaceae.氨基糖苷类药物治疗在感染多黏菌素和碳青霉烯类耐药肠杆菌科的肾移植受者结局中的作用。
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Role of Double-Carbapenem Regimen in the Treatment of Infections due to Carbapenemase Producing Carbapenem-Resistant : A Single-Center, Observational Study.产碳青霉烯酶碳青霉烯类耐药菌感染的治疗中双联碳青霉烯方案的作用：一项单中心、观察性研究。
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本文引用的文献

1
Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?头孢他啶-阿维巴坦和氨曲南能否克服肠杆菌科细菌中金属β-内酰胺酶介导的β-内酰胺耐药性？
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02243-16. Print 2017 Apr.
2
Successful Treatment of Urinary Tract Infection in Kidney Transplant Recipients Caused by Multiresistant Klebsiella pneumoniae Producing New Delhi Metallo-Beta-Lactamase (NDM-1) With Strains Genotyping.肾移植受者中由产新德里金属β-内酰胺酶（NDM-1）的多重耐药肺炎克雷伯菌引起的尿路感染的成功治疗及菌株基因分型
Transplant Proc. 2016 Jun;48(5):1576-9. doi: 10.1016/j.transproceed.2016.01.060.
3
Successful treatment of a disseminated infection with extensively drug-resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin-based multidrug regimen.在一名肝移植受者中，使用基于磷霉素的多药方案成功治疗广泛耐药肺炎克雷伯菌的播散性感染。
Transpl Infect Dis. 2016 Oct;18(5):777-781. doi: 10.1111/tid.12578. Epub 2016 Sep 7.
4
Infections Caused by Resistant Gram-Negative Bacteria: Epidemiology and Management.耐革兰氏阴性菌引起的感染：流行病学与管理
Pharmacotherapy. 2015 Oct;35(10):949-62. doi: 10.1002/phar.1636.
5
In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae.针对产碳青霉烯酶肠杆菌科细菌的双碳青霉烯类联合用药的体外评估
J Antimicrob Chemother. 2016 Jan;71(1):156-61. doi: 10.1093/jac/dkv294. Epub 2015 Sep 27.
6
Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia.产碳青霉烯酶的泛耐药肺炎克雷伯菌菌血症的成功治疗
Antimicrob Agents Chemother. 2015 Oct;59(10):5903-8. doi: 10.1128/AAC.00655-15.
7
Intravenous Fosfomycin Treatment for Carbapenem-Resistant Klebsiella pneumoniae in the United States.
Ann Pharmacother. 2015 Oct;49(10):1177-8. doi: 10.1177/1060028015598326. Epub 2015 Aug 3.
8
Carbapenemase-producing Enterobacteriaceae.产碳青霉烯酶肠杆菌科细菌
Semin Respir Crit Care Med. 2015 Feb;36(1):74-84. doi: 10.1055/s-0035-1544208. Epub 2015 Feb 2.
9
Sepsis caused by New Delhi metallo-β-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review.由产新德里金属β-内酰胺酶（blaNDM-1）和喹诺酮耐药基因qnrD的摩根摩根菌引起的脓毒症，经磷霉素和美罗培南成功治疗：病例报告及文献综述
Int J Infect Dis. 2015 Jan;30:20-6. doi: 10.1016/j.ijid.2014.09.010. Epub 2014 Oct 30.
10
The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies.移植受者和血液系统恶性肿瘤患者中耐碳青霉烯类肠杆菌科细菌的全球挑战。
Clin Infect Dis. 2014 May;58(9):1274-83. doi: 10.1093/cid/ciu052. Epub 2014 Jan 23.

“双碳青霉烯类”联合口服磷霉素治疗肾移植中携带bla的肠杆菌科细菌引起的复杂性尿路感染

"Double carbapenem" and oral fosfomycin for the treatment of complicated urinary tract infections caused by bla -harboring Enterobacteriaceae in kidney transplantation.

作者信息

Rosa Rossana, Rudin Susan D, Rojas Laura J, Hujer Andrea M, Perez-Cardona Armando, Perez Federico, Bonomo Robert A, Martinez Octavio, Abbo Lilian M, Camargo Jose F

机构信息

Department of Medicine, Jackson Memorial Hospital, Miami, FL, USA.

Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.

出版信息

Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12795. Epub 2017 Nov 27.

DOI:10.1111/tid.12795
PMID:29064133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5809302/
Abstract

Infections with carbapenemase-producing carbapenem-resistant Enterobacteriaceae represent an emergent problem worldwide. Treatment of infections caused by New Delhi metallo-beta-lactamase (NDM)-harboring Enterobacteriaceae is particularly challenging as it frequently involves the use of nephrotoxic agents, which is problematic in kidney transplant recipients and non-renal transplant patients with marginal kidney function. We present two cases of urinary tract infections caused by NDM-harboring Enterobacteriaceae successfully treated with a combination of "double carbapenem" and oral fosfomycin.

摘要

产碳青霉烯酶的耐碳青霉烯类肠杆菌科细菌感染是全球范围内出现的一个问题。由携带新德里金属β-内酰胺酶（NDM）的肠杆菌科细菌引起的感染治疗尤其具有挑战性，因为治疗常常涉及使用肾毒性药物，这对于肾移植受者以及肾功能不佳的非肾移植患者来说是个难题。我们报告了两例由携带NDM的肠杆菌科细菌引起的尿路感染病例，采用“双碳青霉烯”联合口服磷霉素成功治愈。