Candrina R, Cerudelli B, Braga V, Salvi A
Istituto di Patologia Medica, University of Brescia, Italy.
J Endocrinol Invest. 1989 Jan;12(1):55-7. doi: 10.1007/BF03349921.
We examined the effects of the acute administration of salmon calcitonin on phosphate metabolism in tumoral calcinosis. On two different days, 200 MRC U of the synthetic hormone were administered sc to a 38-year-old patient, either as twice daily 100 MRC U injections, or as a continuous sc infusion via a portable pump. Both ways of calcitonin administration elicited a phosphaturic effect and a lowering of serum phosphate level comparable with that observed after an iv infusion of calcitonin. 1,25 dihydroxyvitamin D level, which was in the normal range during a control study, increased after calcitonin administration. In our patient, long term therapy with diet, a phosphate-binding agent and calcitonin prevented the occurrence of new ectopic calcifications. Owing to its phosphaturic activity, synthetic salmon calcitonin may be a useful adjunct to diet and aluminium-containing antacids in long-term management of tumoral calcinosis.
我们研究了急性给予鲑鱼降钙素对肿瘤性钙化中磷代谢的影响。在两个不同的日子里，将200 MRC U的合成激素皮下注射给一名38岁的患者，要么每日两次，每次注射100 MRC U，要么通过便携式泵进行持续皮下输注。两种降钙素给药方式均引发了排磷作用，并使血清磷水平降低，这与静脉输注降钙素后观察到的情况相当。在对照研究期间处于正常范围的1,25-二羟维生素D水平在给予降钙素后升高。在我们的患者中，通过饮食、磷结合剂和降钙素进行长期治疗可预防新的异位钙化的发生。由于其排磷活性，合成鲑鱼降钙素在肿瘤性钙化的长期管理中可能是饮食和含铝抗酸剂的有用辅助药物。
