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氨苯砜治疗的麻风分枝杆菌感染小鼠的体液免疫反应。

Humoral immune responses in dapsone treated M. leprae infected mice.

作者信息

Srinivasan R, Rao P R

机构信息

Dept. of Pediatrics, Cornell Medical Centre, New York, NY 10021.

出版信息

Indian J Lepr. 1989 Apr;61(2):151-9.

PMID:2746024
Abstract

Humoral responses in M. leprae infected mice were studied through 52 weeks and were found to be directly related to the bacterial load. However, treatment with dapsone (DDS) in the last 12 weeks of infection resulted in an initial enhancement of the humoral responses followed by a gradual decrease, though they were still significantly high at the end of the study.

摘要

对感染麻风分枝杆菌的小鼠的体液免疫反应进行了长达52周的研究,发现其与细菌载量直接相关。然而,在感染的最后12周用氨苯砜(DDS)治疗,导致体液免疫反应最初增强,随后逐渐下降,尽管在研究结束时它们仍显著高于正常水平。

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