George J, Balakrishnan S
Indian J Lepr. 1986 Jul-Sep;58(3):401-6.
The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days. Plasma levels of DDS were determined on the 2nd, 7th, 15th, 30th, 60th and 75th day after administration of the drug by spectrophoto-fluorometric technique. The mean peak levels of DDS (85.36 ng/ml) were noticed on 7th day followed by a gradual decrease in DDS concentration. The mean half-life level (44.53 ng/ml) of DDS were observed around the 15th day. The mean DDS level for the entire period of observation after one dose was 41.95 ng/ml. On the 75th day, the DDS level reached the minimum value of 14.76 ng/ml which was still about 5 times more than the minimal inhibitory concentration (MIC) level of DDS against M. leprae (3 ng/ml). The results are discussed.
在15名接受225毫克醋氨苯砜（DADDS，4,4'-二乙酰二氨基二苯砜）肌肉注射，为期75天的个体中，对储存药物醋氨苯砜的代谢情况进行了研究。在给药后的第2天、第7天、第15天、第30天、第60天和第75天，采用分光光度荧光法测定血浆中氨苯砜（DDS）的水平。DDS的平均峰值水平（85.36纳克/毫升）在第7天被注意到，随后DDS浓度逐渐下降。在第15天左右观察到DDS的平均半衰期水平（44.53纳克/毫升）。一剂药物后整个观察期的DDS平均水平为41.95纳克/毫升。在第75天，DDS水平达到最小值14.76纳克/毫升，这仍比DDS对麻风杆菌的最低抑菌浓度（MIC）水平（3纳克/毫升）高约5倍。对结果进行了讨论。
