Gulati Susheel, Singh Rajvir, Sangwan Suman
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University Hisar 125004 India
RSC Adv. 2021 Sep 1;11(47):29130-29155. doi: 10.1039/d1ra04887b.
Due to growing concern about chemicals and their impact on the environment, cleaner reaction conditions are needed to be incorporated into chemical synthetic procedures. Recently, the use of heteropolyacid catalysts, mainly reuseable solid acid catalysts, has gained a leading role in organic synthesis due to their environmental and economic considerations and industrial utilization. The high catalytic activity, moisture sensitivity, reusability and inexpensive makes solid supported reagents attractive substituents to conventional Lewis acids. Nowadays synthesis of coumarins and their derivatives has attracted considerable attention from organic and medicinal chemists for many years as a large number of natural products contain this heterocyclic nucleus. In continuation with our investigations into the synthesis of substituted coumarins and due to several advantages of heterogeneous catalysts cost-effective, no side products, high yield of desired products and no toxic waste material, here we report a new approach for the synthesis of substituted coumarins using solid acid catalysts.
由于对化学品及其对环境影响的关注度不断提高，需要将更清洁的反应条件纳入化学合成程序中。最近，杂多酸催化剂（主要是可重复使用的固体酸催化剂）的使用，因其环境和经济方面的考虑以及工业应用，在有机合成中占据了主导地位。高催化活性、对水分敏感、可重复使用且价格低廉，使得固体负载试剂成为传统路易斯酸颇具吸引力的替代品。多年来，香豆素及其衍生物的合成一直吸引着有机化学家和药物化学家的广泛关注，因为大量天然产物都含有这种杂环核。在继续我们对取代香豆素合成的研究过程中，鉴于多相催化剂具有成本效益、无副产物、目标产物产率高且无有毒废料等诸多优点，在此我们报告一种使用固体酸催化剂合成取代香豆素的新方法。
