通过聚乙二醇的后聚合氧官能化合成可降解聚[（乙二醇）-共-（乙醇酸）]

Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol).

作者信息

Liu Di, Bielawski Christopher W

机构信息

Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.

Center for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS), Ulsan, 44919, Republic of Korea.

出版信息

Macromol Rapid Commun. 2016 Oct;37(19):1587-1592. doi: 10.1002/marc.201600336. Epub 2016 Jul 27.

DOI:10.1002/marc.201600336

PMID:27461401

Abstract

To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium-catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions.

摘要

为提高聚乙二醇（PEG）有限的可降解性，开发了一种直接的方法，即通过钌催化各种PEG的后聚合氧官能化来合成聚（乙二醇 - 共 - 乙醇酸）（P（EG - co - GA））。使用该方法，制备了一组GA组成高达8 mol%的共聚物，与市售起始材料相比，分子量降低最小（<10%）。结果表明，P（EG - co - GA）共聚物在温和条件下会发生水解。