Omae Kenichi, Hiraki Takao, Gobara Hideo, Iguchi Toshihiro, Fujiwara Hiroyasu, Matsui Yusuke, Toyooka Shinichi, Nagasaka Takeshi, Kanazawa Susumu
Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, Kita-ku, Okayama 700-8558, Japan.
Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, Kita-ku, Okayama 700-8558, Japan.
J Vasc Interv Radiol. 2016 Sep;27(9):1362-1370. doi: 10.1016/j.jvir.2016.05.017. Epub 2016 Jul 22.
To conduct a retrospective evaluation of long-term survival after radiofrequency (RF) ablation for lung oligometastases from 5 types of primary lesions.
The study population consisted of 123 patients with lung oligometastases from colorectal cancer (CRC), non-small-cell lung cancer, hepatocellular carcinoma, esophageal cancer, and renal-cell carcinoma treated with RF ablation. Lung oligometastases were defined as 1-5 metastases confined to the lung while the primary cancer and other metastases were eradicated. Overall survival (OS) and recurrence-free survival (RFS) were estimated for the overall study population and for patients with each type of primary lesion. The OS and RFS rates were compared with those of the patients with any of the other four primary lesion types. Finally, various variables were analyzed to determine what factors influenced OS and RFS.
The median follow-up was 45.7 months, and the 5-year OS and RFS rates for all 123 patients were 62% and 25%, respectively. The OS time for patients with metastases from CRC was significantly longer (P = .042); it was significantly shorter (P = .022) in patients with metastases from esophageal cancer. Longer disease-free interval was significantly (P = .015) associated with better OS. There was no variable significantly associated with OS and RFS on multivariate analyses.
Data from this single-center study appear promising in terms of long-term survival after RF ablation of lung oligometastases from 5 primary lesions.
对5种原发性病变的肺寡转移灶进行射频消融术后的长期生存情况进行回顾性评估。
研究人群包括123例接受射频消融治疗的结直肠癌、非小细胞肺癌、肝细胞癌、食管癌和肾细胞癌肺寡转移灶患者。肺寡转移灶定义为局限于肺部的1 - 5个转移灶，同时原发性癌症和其他转移灶已被根除。对整个研究人群以及每种原发性病变类型的患者进行总生存期（OS）和无复发生存期（RFS）评估。将OS和RFS率与其他四种原发性病变类型中任何一种的患者进行比较。最后，分析各种变量以确定哪些因素影响OS和RFS。
中位随访时间为45.7个月，123例患者的5年OS率和RFS率分别为62%和25%。结直肠癌转移患者的OS时间显著更长（P = .042）；食管癌转移患者的OS时间显著更短（P = .022）。更长的无病间期与更好的OS显著相关（P = .015）。多因素分析中没有变量与OS和RFS显著相关。
这项单中心研究的数据显示，对5种原发性病变的肺寡转移灶进行射频消融术后的长期生存情况颇具前景。
