Katakwar Payal, Metgud Rashmi, Naik Smitha, Mittal Rashu
Department of Oral Pathology and Microbiology, Pacific Dental College and Hospital, Debari, Udaipur, Rajasthan, India.
Department of ENT, G.S. Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India.
J Cancer Res Ther. 2016 Apr-Jun;12(2):438-46. doi: 10.4103/0973-1482.151935.
Oxygen derived species such as hydrogen peroxide, superoxide anion radical, hydroxyl radical (OH-), and singlet oxygen are well known to be cytotoxic and have been implicated in the etiology of a wide array of human diseases, including cancer. Various carcinogens may also partly exert their effect by generating reactive oxygen species (ROS) during their metabolism. Oxidative damage to cellular DNA can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. ROS influences central cellular processes such as proliferation, apoptosis, and senescence which are implicated in the development of cancer. Understanding the role of ROS as key mediators in signaling cascades may provide various opportunities for pharmacological intervention.
诸如过氧化氢、超氧阴离子自由基、羟基自由基（OH-）和单线态氧等氧衍生物种众所周知具有细胞毒性，并与包括癌症在内的多种人类疾病的病因有关。各种致癌物在其代谢过程中也可能通过产生活性氧（ROS）部分发挥其作用。对细胞DNA的氧化损伤可导致突变，因此可能在多阶段致癌作用的起始和进展中起重要作用。ROS影响细胞增殖、凋亡和衰老等核心细胞过程，这些过程与癌症的发展有关。了解ROS作为信号级联反应中的关键介质的作用可能为药物干预提供各种机会。
