中枢神经系统对酒精的炎症反应：核受体作为酒精诱导神经病理学的潜在治疗手段。
Inflammatory responses to alcohol in the CNS: nuclear receptors as potential therapeutics for alcohol-induced neuropathologies.
作者信息
Kane Cynthia J M, Drew Paul D
机构信息
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
出版信息
J Leukoc Biol. 2016 Nov;100(5):951-959. doi: 10.1189/jlb.3MR0416-171R. Epub 2016 Jul 26.
Abstract
Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that observed in the CNS. It is now appreciated in both humans and animal models that ethanol can induce inflammation in the CNS. Neuroinflammation is hypothesized to contribute to the neuropathologic and behavioral consequences in FASD and AUD. In this review, we: 1) summarize the evidence of alcohol-induced CNS inflammation, 2) outline cellular and molecular mechanisms that may underlie alcohol induction of CNS inflammation, and 3) discuss the potential of nuclear receptor agonists for prevention or treatment of neuropathologies associated with FASD and AUD.
摘要
胎儿酒精谱系障碍（FASD）由孕期接触乙醇所致，而酒精使用障碍（AUD）包括暴饮和慢性酒精滥用，这两种病症在个人和社会层面都极为常见且代价高昂。这些病症与重大病理状况相关，包括中枢神经系统（CNS）中观察到的病理状况。目前在人类和动物模型中均已认识到，乙醇可在中枢神经系统中诱发炎症。神经炎症被认为是导致FASD和AUD中神经病理和行为后果的原因。在本综述中，我们：1）总结酒精诱发中枢神经系统炎症的证据，2）概述可能是酒精诱发中枢神经系统炎症基础的细胞和分子机制，3）讨论核受体激动剂在预防或治疗与FASD和AUD相关的神经病理方面的潜力。
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本文引用的文献
1
The force awakens: insights into the origin and formation of microglia.
Curr Opin Neurobiol. 2016 Aug;39:30-7. doi: 10.1016/j.conb.2016.04.003. Epub 2016 Apr 22.
2
Microglia: Architects of the Developing Nervous System.
Trends Cell Biol. 2016 Aug;26(8):587-597. doi: 10.1016/j.tcb.2016.02.006. Epub 2016 Mar 20.
3
Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus.
Neuroscience. 2016 Jun 2;324:355-66. doi: 10.1016/j.neuroscience.2016.03.033. Epub 2016 Mar 18.
4
Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling.
Immunity. 2016 Mar 15;44(3):505-515. doi: 10.1016/j.immuni.2016.02.013.
5
PPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice.
Alcohol Clin Exp Res. 2016 Mar;40(3):553-62. doi: 10.1111/acer.12976. Epub 2016 Feb 9.
6
Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence.
Brain Behav Immun. 2016 Mar;53:159-171. doi: 10.1016/j.bbi.2015.12.006. Epub 2015 Dec 10.
7
Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4.
Br J Pharmacol. 2016 Mar;173(5):856-69. doi: 10.1111/bph.13394. Epub 2016 Feb 4.
8
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation.
Curr Opin Pharmacol. 2016 Feb;26:96-101. doi: 10.1016/j.coph.2015.10.009. Epub 2015 Nov 18.
9
N-Docosahexaenoylethanolamine ameliorates ethanol-induced impairment of neural stem cell neurogenic differentiation.
Neuropharmacology. 2016 Mar;102:174-85. doi: 10.1016/j.neuropharm.2015.11.011. Epub 2015 Nov 14.
10
Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders.
Biochem Pharmacol. 2016 Mar 1;103:1-16. doi: 10.1016/j.bcp.2015.11.003. Epub 2015 Nov 7.
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