Chowdhury Zahid Sadek, Morshed Mohammed Monzur, Shahriar Mohammad, Bhuiyan Mohiuddin Ahmed, Islam Sardar Mohd Ashraful, Bin Sayeed Muhammad Shahdaat
Department of Pharmacy, University of Asia Pacific, Dhaka 1209, Bangladesh.
Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.
Behav Neurol. 2016;2016:3730940. doi: 10.1155/2016/3730940. Epub 2016 Jul 4.
Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks. We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB) software to assess the chronic effect of alprazolam. We selected Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) tests for memory, Rapid Visual Information Processing (RVP) for attention, and Choice Reaction Time (CRT) for psychomotor performance twice: before starting the treatment and after the completion of the treatment. We found statistically significant impairment of visual memory in one parameter of PAL and three parameters of DMS in alprazolam group. The PAL mean trial to success and total correct matching in 0-second delay, 4-second delay, and all delay situation of DMS were impaired in alprazolam group. RVP total hits after two weeks of alprazolam treatment were improved in alprazolam group. But such differences were not observed in placebo group. In our study, we found that chronic administration of alprazolam affects memory but attentive and psychomotor performance remained unaffected.
阿普唑仑用作治疗广泛性焦虑症的抗焦虑药物，据报道它会产生镇静作用和顺行性遗忘。在本研究中，我们将26名健康男性志愿者随机分为两组：一组每天服用0.5毫克阿普唑仑，另一组每天服用安慰剂，为期两周。我们使用剑桥神经心理测试自动成套系统（CANTAB）软件来评估阿普唑仑的长期影响。我们选择了配对联想学习（PAL）和延迟匹配样本（DMS）测试来评估记忆，快速视觉信息处理（RVP）测试来评估注意力，以及选择反应时间（CRT）测试来评估心理运动表现，在治疗开始前和治疗结束后各进行两次测试。我们发现阿普唑仑组在PAL的一个参数和DMS的三个参数中存在视觉记忆的统计学显著损伤。阿普唑仑组在PAL的成功平均试验次数以及DMS在0秒延迟、4秒延迟和所有延迟情况下的总正确匹配次数均受损。阿普唑仑组在阿普唑仑治疗两周后的RVP总命中次数有所改善。但安慰剂组未观察到此类差异。在我们的研究中，我们发现长期服用阿普唑仑会影响记忆，但注意力和心理运动表现不受影响。
