Moghaddassi Maryam, Togha Mansoureh, Shahram Farhad, Hanif Hamed, Dadkhah Sahar, Jahromi Soodeh Razeghi, Mozafari Mohammad
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran ; Department of Neurology, Neurology Ward, Sina Hospital, Tehran University of Medical Sciences, Hassan Abad Square, Tehran, 1136746911 Iran.
Springerplus. 2016 Jul 13;5(1):1077. doi: 10.1186/s40064-016-2721-4. eCollection 2016.
Behcet's disease involves several systems in the body. Neurological involvement is identified by different symptoms. Headache is one of the common complaints of patients with Behcet's disease. It might be a part of neurological involvement or may arise independently in the course of disease. Studies with small sample size have resulted in various findings in this field. Since the prevalence of Behcet's disease is relatively high in Iran, this study was carried out to compare the features of headache between an acceptable number of patients with this rare disease and a control group.
The current case-control study was performed to compare the features of headache between 312 patients with definite Behcet's disease who referred to a Behcet's clinic and healthy individuals. Patients with Behcet's disease were randomly selected. Controls were matched for age and sex. They were personally examined and interviewed meticulously using a questionnaire that met the standards of the International Headache Society classification for different types of headache.
The incidence of headache in the case and control groups was 28.3 % (n = 120) and 18.6 % (n = 59), respectively (p < 0.05; OR 2.73). Tension-type headache was observed in 12.2 % (n = 38) of cases which was significantly higher than control group (n = 6.3 %) (p = 0.011; OR 2.05). The most frequent type of headache in the case group was tension-type headache (12.2 %). In the control group, however, migraine without aura was the most common type (9.1 %). A correlation between ophthalmological involvement and headache was observed in 11 patients in the case group. In addition, a significantly higher systolic blood pressure was found in the case group compared to the controls (125.1 vs. 121.7 mmHg; p = 0.007). There was no major correlation between prednisolone consumption in patients with Behcet's disease and the type and frequency of headache.
Headache, especially tension-type headache, is more common in patients with Behcet's disease. This might be the result of specific types of uveitis-related and non-structural headaches seen in Behcet's disease.
白塞病累及身体多个系统。神经系统受累表现为不同症状。头痛是白塞病患者常见的主诉之一。它可能是神经系统受累的一部分，也可能在疾病过程中独立出现。小样本研究在该领域得出了各种结果。由于伊朗白塞病的患病率相对较高，本研究旨在比较一定数量的这种罕见疾病患者与对照组之间头痛的特征。
进行了一项病例对照研究，以比较312名到白塞病诊所就诊的确诊白塞病患者与健康个体之间头痛的特征。白塞病患者是随机选取的。对照组在年龄和性别上进行了匹配。使用符合国际头痛协会不同类型头痛分类标准的问卷对他们进行了细致的体格检查和访谈。
病例组和对照组头痛的发生率分别为28.3%（n = 120）和18.6%（n = 59）（p < 0.05；OR 2.73）。12.2%（n = 38）的病例出现紧张型头痛，显著高于对照组（n = 6.3%）（p = 0.011；OR 2.05）。病例组中最常见的头痛类型是紧张型头痛（12.2%）。然而，在对照组中，无先兆偏头痛是最常见的类型（9.1%）。病例组中有11名患者观察到眼科受累与头痛之间存在相关性。此外，病例组的收缩压明显高于对照组（125.1对121.7 mmHg；p = 0.007）。白塞病患者使用泼尼松龙与头痛的类型和频率之间没有主要相关性。
头痛，尤其是紧张型头痛，在白塞病患者中更为常见。这可能是白塞病中特定类型的葡萄膜炎相关和非结构性头痛的结果。
