骨骼肌中运动刺激的葡萄糖摄取的调节
Regulation of exercise-stimulated glucose uptake in skeletal muscle.
作者信息
Koh Ho-Jin
机构信息
Applied Physiology Division, Department of Exercise Science, Arnold School of Public Health, Univer sity of South Carolina, Columbia, SC, USA.
出版信息
Ann Pediatr Endocrinol Metab. 2016 Jun;21(2):61-5. doi: 10.6065/apem.2016.21.2.61. Epub 2016 Jun 30.
Abstract
AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that has been thought to be an important mediator for exercise-stimulated glucose uptake in skeletal muscle. Liver kinase B1 (LKB1) is an upstream kinase for AMPK and AMPK-related protein kinases, of which the function in skeletal muscle has not been well documented. Our group and others have generated mice lacking AMPK activity in skeletal muscle, as well as muscle-specific LKB1 knockout mice. In this review, we discuss the potential role of AMPK and LKB1 in regulating exercise-stimulated glucose uptake in skeletal muscle. We also discuss our recent study, demonstrating the molecular mechanism of obesity-induced development of skeletal muscle insulin resistance.
摘要
AMP激活的蛋白激酶（AMPK）是一种丝氨酸/苏氨酸激酶，一直被认为是运动刺激骨骼肌摄取葡萄糖的重要介质。肝脏激酶B1（LKB1）是AMPK及AMPK相关蛋白激酶的上游激酶，其在骨骼肌中的功能尚未得到充分证实。我们团队及其他团队已培育出骨骼肌中缺乏AMPK活性的小鼠，以及肌肉特异性LKB1基因敲除小鼠。在这篇综述中，我们讨论了AMPK和LKB1在调节运动刺激骨骼肌摄取葡萄糖方面的潜在作用。我们还讨论了我们最近的研究，该研究揭示了肥胖诱导骨骼肌胰岛素抵抗发生发展的分子机制。
相似文献
1
Regulation of exercise-stimulated glucose uptake in skeletal muscle.
Ann Pediatr Endocrinol Metab. 2016 Jun;21(2):61-5. doi: 10.6065/apem.2016.21.2.61. Epub 2016 Jun 30.
2
Postexercise improvement in glucose uptake occurs concomitant with greater γ3-AMPK activation and AS160 phosphorylation in rat skeletal muscle.
Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E859-E871. doi: 10.1152/ajpendo.00020.2018. Epub 2018 Aug 21.
3
Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm.
Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E213-29. doi: 10.1152/ajpendo.00114.2013. Epub 2013 May 21.
4
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.
Mol Cell Endocrinol. 2013 Feb 25;366(2):135-51. doi: 10.1016/j.mce.2012.06.019. Epub 2012 Jun 28.
5
Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.
Am J Physiol Endocrinol Metab. 2007 May;292(5):E1308-17. doi: 10.1152/ajpendo.00456.2006. Epub 2007 Jan 9.
6
Exercise training reduces the insulin-sensitizing effect of a single bout of exercise in human skeletal muscle.
J Physiol. 2019 Jan;597(1):89-103. doi: 10.1113/JP276735. Epub 2018 Nov 22.
7
The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.
Mol Metab. 2015 Jun 15;4(9):643-51. doi: 10.1016/j.molmet.2015.06.002. eCollection 2015 Sep.
8
Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.
Diabetes. 2007 May;56(5):1403-9. doi: 10.2337/db06-1230. Epub 2007 Feb 7.
9
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.
Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. doi: 10.1152/ajpendo.00074.2004. Epub 2004 Apr 6.
10
Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2.
Sports Med Health Sci. 2022 Aug 28;5(1):34-41. doi: 10.1016/j.smhs.2022.08.001. eCollection 2023 Mar.
引用本文的文献
1
Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.
Mol Cell Biol. 2022 Jan 20;42(1):e0032721. doi: 10.1128/MCB.00327-21. Epub 2021 Oct 25.
2
Influence of exercise training on diabetic kidney disease: A brief physiological approach.
Exp Biol Med (Maywood). 2020 Jul;245(13):1142-1154. doi: 10.1177/1535370220928986. Epub 2020 Jun 2.
3
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Int J Mol Sci. 2018 Oct 9;19(10):3076. doi: 10.3390/ijms19103076.
4
Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization.
Genes Dev. 2018 Jan 15;32(2):156-164. doi: 10.1101/gad.305870.117. Epub 2018 Feb 9.
5
Comorbidity Analysis between Alzheimer's Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs.
J Alzheimers Dis. 2017;60(2):721-731. doi: 10.3233/JAD-170440.
本文引用的文献
1
The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.
J Clin Invest. 2016 Feb;126(2):560-70. doi: 10.1172/JCI79197.
2
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.
Nat Commun. 2013;4:1871. doi: 10.1038/ncomms2851.
3
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.
J Biol Chem. 2010 Nov 26;285(48):37198-209. doi: 10.1074/jbc.M110.102434. Epub 2010 Sep 20.
4
Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15541-6. doi: 10.1073/pnas.1008131107. Epub 2010 Aug 16.
5
TRB3 function in cardiac endoplasmic reticulum stress.
Circ Res. 2010 May 14;106(9):1516-23. doi: 10.1161/CIRCRESAHA.109.211920. Epub 2010 Apr 1.
6
Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.
Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E924-34. doi: 10.1152/ajpendo.90653.2008. Epub 2009 Aug 4.
7
Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo.
J Biol Chem. 2009 Sep 4;284(36):23925-34. doi: 10.1074/jbc.M109.021048. Epub 2009 Jun 12.
8
The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro.
Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1447-54. doi: 10.1152/ajpendo.90362.2008. Epub 2008 Sep 23.
9
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Mol Cell Biol. 2006 Nov;26(22):8217-27. doi: 10.1128/MCB.00979-06. Epub 2006 Sep 11.
10
Glucose, dexamethasone, and the unfolded protein response regulate TRB3 mRNA expression in 3T3-L1 adipocytes and L6 myotubes.
Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1274-80. doi: 10.1152/ajpendo.00117.2006. Epub 2006 Jul 11.
Zotero 插件