Avilés A, Díaz-Maqueo J C, de la Torre A, Rodriguez L, Guzmán R, Talavera A, García E L
a Department of Hematology, Oncology Hospital, National Medical Center. I.M.S.S., Mexico, DF, Mexico.
b Endoscopy, Oncology Hospital, National Medical Center. I.M.S.S, Mexico, DF, Mexico.
Leuk Lymphoma. 1991;5(5-6):365-9. doi: 10.3109/10428199109067630.
Fifty-two patients with primary gastric lymphoma were randomly assigned to two different surgical approaches. Twenty-eight cases were diagnosed by endoscopy and treated with chemotherapy CHOP-Bleo (cyclophosphamide, adriamycin, vincristine, prednisone and bleomycin) alternating with CMED (cyclophosphamide, metothexate, etoposide and dexamethasone). Twenty four cases underwent debulking surgery (partial or total gastrectomy) followed by the same chemotherapy. No differences were observed in relapse free disease or survival in resected or unresected patients. Complications were more frequent and severe in patients who underwent surgery. We believe that surgery is not necessary in the treatment of patients with primary gastric lymphoma.
52例原发性胃淋巴瘤患者被随机分配至两种不同的手术方式。28例经内镜诊断，并接受CHOP-Bleo（环磷酰胺、阿霉素、长春新碱、泼尼松和博来霉素）与CMED（环磷酰胺、甲氨蝶呤、依托泊苷和地塞米松）交替化疗。24例接受减瘤手术（部分或全胃切除术），随后接受相同的化疗。在接受或未接受手术的患者中，无病生存率或总生存率未见差异。接受手术的患者并发症更频繁且更严重。我们认为原发性胃淋巴瘤患者的治疗无需手术。
