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[老年肾移植]

[Kidney transplantation in old age].

作者信息

Kurschat C

机构信息

Klinik II für Innere Medizin, Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

出版信息

Z Gerontol Geriatr. 2016 Aug;49(6):488-93. doi: 10.1007/s00391-016-1118-x. Epub 2016 Jul 27.

DOI:10.1007/s00391-016-1118-x
PMID:27464740
Abstract

Older patients clearly benefit from a kidney transplantation despite multiple comorbidities and complications, particularly with respect to life expectancy. Older patients remaining on dialysis on average die earlier compared to patients who underwent a kidney transplantation. In addition, patients experience a significant increase in the quality of life after renal transplantation. However, every patient has to be thoroughly evaluated to assess the individual benefits of a renal transplantation. Geriatric tools are particularly helpful to evaluate the suitability of older individuals. In 1999 the Eurotransplant senior program (ESP or "old for old") was initiated, aiming at shortening waiting time and cold ischemia time for patients on the waiting list. In this program, kidneys of donors aged 65 years and older are locally allocated to recipients also of 65 years and older. The results in ESP are promising, to the effect that this program helps older patients to receive a kidney transplant earlier than by the normal procedure; however, a better alternative to the ESP program is living donor transplantation, provided that a suitable donor is available. There is no age limit for the evaluation of potential donors. Compared to deceased donor kidney transplantation a living donor kidney will most likely function with a higher spontaneous rate and for a longer period of time and therefore provides a clear advantage for older recipients.

摘要

尽管存在多种合并症和并发症,但老年患者显然能从肾移植中获益,尤其是在预期寿命方面。与接受肾移植的患者相比,继续接受透析治疗的老年患者平均死亡更早。此外,肾移植后患者的生活质量会显著提高。然而,必须对每位患者进行全面评估,以评估肾移植的个体获益情况。老年评估工具对评估老年人的适用性特别有帮助。1999年启动了欧洲移植老年项目(ESP或“老年对老年”),旨在缩短等待名单上患者的等待时间和冷缺血时间。在该项目中,65岁及以上供体的肾脏在当地分配给同样65岁及以上的受者。ESP项目的结果很有前景,该项目帮助老年患者比通过正常程序更早地接受肾移植;然而,如果有合适的供体,对ESP项目更好的替代方案是活体供体移植。对潜在供体的评估没有年龄限制。与尸体供肾移植相比,活体供肾移植更有可能以更高的自发率和更长的时间发挥功能,因此对老年受者具有明显优势。

相似文献

1
[Kidney transplantation in old age].[老年肾移植]
Z Gerontol Geriatr. 2016 Aug;49(6):488-93. doi: 10.1007/s00391-016-1118-x. Epub 2016 Jul 27.
2
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BMC Health Serv Res. 2024 Jun 24;24(1):763. doi: 10.1186/s12913-024-11200-y.
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Prognostic Signature of Chronic Kidney Disease in Advanced Age: Secondary Analysis from the InGAH Study with One-Year Follow-Up.高龄慢性肾脏病的预后特征:来自 INGAH 研究的一年随访二次分析。
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The emerging role of cellular senescence in renal diseases.

本文引用的文献

1
'I feel stronger and younger all the time'-perspectives of elderly kidney transplant recipients: thematic synthesis of qualitative research.“我一直感觉更强壮、更年轻”——老年肾移植受者的观点:定性研究的主题综合分析
Nephrol Dial Transplant. 2016 Sep;31(9):1531-40. doi: 10.1093/ndt/gfv463. Epub 2016 Feb 4.
2
Acceptability of older adults as living kidney donors.老年人作为活体肾供体的可接受性。
Curr Opin Nephrol Hypertens. 2016 May;25(3):245-56. doi: 10.1097/MNH.0000000000000215.
3
Mortality on the Kidney Waiting List and After Transplantation in Patients With Peripheral Arterial Disease: An Analysis of the United States Renal Data System.
细胞衰老在肾脏疾病中的新兴作用。
J Cell Mol Med. 2020 Feb;24(3):2087-2097. doi: 10.1111/jcmm.14952. Epub 2020 Jan 8.
外周动脉疾病患者肾移植等待名单上及移植后的死亡率:美国肾脏数据系统分析
Transplant Proc. 2016 Jan-Feb;48(1):15-20. doi: 10.1016/j.transproceed.2015.11.005.
4
Incidence and Long-Term Prognosis of Cancer After Kidney Transplantation.肾移植后癌症的发病率及长期预后
Transplant Proc. 2015 Nov;47(9):2618-21. doi: 10.1016/j.transproceed.2015.08.043.
5
A simple clinical tool to inform the decision-making process to refer elderly incident dialysis patients for kidney transplant evaluation.一个简单的临床工具,用于为老年偶发透析患者的肾脏移植评估提供决策依据。
Kidney Int. 2015 Jul;88(1):121-9. doi: 10.1038/ki.2015.25. Epub 2015 Feb 11.
6
Assessment of health-related quality of life of patients after kidney transplantation in comparison with hemodialysis and peritoneal dialysis.肾移植患者与血液透析和腹膜透析患者相比的健康相关生活质量评估。
Ann Transplant. 2014 Nov 9;19:576-85. doi: 10.12659/AOT.891265.
7
Clinical issues in renal transplantation in the elderly.老年肾移植的临床问题
Clin Transplant. 2015 Feb;29(2):167-75. doi: 10.1111/ctr.12481. Epub 2015 Jan 5.
8
Frailty and mortality in kidney transplant recipients.肾移植受者的衰弱与死亡率
Am J Transplant. 2015 Jan;15(1):149-54. doi: 10.1111/ajt.12992. Epub 2014 Oct 30.
9
Quality of life in elderly kidney transplant recipients.老年肾移植受者的生活质量
J Am Geriatr Soc. 2014 Oct;62(10):1877-82. doi: 10.1111/jgs.13065. Epub 2014 Oct 3.
10
Renal transplantation in elderly patients. How to select the candidates to the waiting list?老年患者的肾移植。如何选择等待名单上的候选人?
Transplant Rev (Orlando). 2014 Oct;28(4):188-92. doi: 10.1016/j.trre.2014.07.001. Epub 2014 Jul 31.