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[老年肾移植]

[Kidney transplantation in old age].

作者信息

Kurschat C

机构信息

Klinik II für Innere Medizin, Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

出版信息

Z Gerontol Geriatr. 2016 Aug;49(6):488-93. doi: 10.1007/s00391-016-1118-x. Epub 2016 Jul 27.

Abstract

Older patients clearly benefit from a kidney transplantation despite multiple comorbidities and complications, particularly with respect to life expectancy. Older patients remaining on dialysis on average die earlier compared to patients who underwent a kidney transplantation. In addition, patients experience a significant increase in the quality of life after renal transplantation. However, every patient has to be thoroughly evaluated to assess the individual benefits of a renal transplantation. Geriatric tools are particularly helpful to evaluate the suitability of older individuals. In 1999 the Eurotransplant senior program (ESP or "old for old") was initiated, aiming at shortening waiting time and cold ischemia time for patients on the waiting list. In this program, kidneys of donors aged 65 years and older are locally allocated to recipients also of 65 years and older. The results in ESP are promising, to the effect that this program helps older patients to receive a kidney transplant earlier than by the normal procedure; however, a better alternative to the ESP program is living donor transplantation, provided that a suitable donor is available. There is no age limit for the evaluation of potential donors. Compared to deceased donor kidney transplantation a living donor kidney will most likely function with a higher spontaneous rate and for a longer period of time and therefore provides a clear advantage for older recipients.

摘要

尽管存在多种合并症和并发症,但老年患者显然能从肾移植中获益,尤其是在预期寿命方面。与接受肾移植的患者相比,继续接受透析治疗的老年患者平均死亡更早。此外,肾移植后患者的生活质量会显著提高。然而,必须对每位患者进行全面评估,以评估肾移植的个体获益情况。老年评估工具对评估老年人的适用性特别有帮助。1999年启动了欧洲移植老年项目(ESP或“老年对老年”),旨在缩短等待名单上患者的等待时间和冷缺血时间。在该项目中,65岁及以上供体的肾脏在当地分配给同样65岁及以上的受者。ESP项目的结果很有前景,该项目帮助老年患者比通过正常程序更早地接受肾移植;然而,如果有合适的供体,对ESP项目更好的替代方案是活体供体移植。对潜在供体的评估没有年龄限制。与尸体供肾移植相比,活体供肾移植更有可能以更高的自发率和更长的时间发挥功能,因此对老年受者具有明显优势。

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